摘要
以邻硝基苯乙酮为初始原料,通过α-溴代、还原环合、开环、酯化获得了二溴代的光敏感交联剂。以叔丁氧羰基乙醇胺(Boc-乙醇胺)为原料通过酯化和脱保护获得了含氨基的自由基引发剂。通过两步原子转移自由基聚合、氨基与羧基之间的酰基化反应、叔胺与交联剂之间的烷基化反应,合成含光敏感交联剂的两亲聚合物[LA-PPEGMA-P(MMA-co-DAEMA)-CL]。采用FTIR、^(1)H NMR确定了聚合物的结构。该聚合物的临界胶束浓度为0.0629 mg/mL,形成胶束的粒径为359.2 nm,Zeta电位为27.9 mV。该胶束具有光敏感性,且pH=6.5、7.4时光敏感性最为显著。
Using o-nitroacetophenone as the initial raw material,dibromo photosensitive crosslinkers were obtained byα-bromination,reductive cyclization,ring opening and esterification.A free radical initiator containing amino was obtained by esterification and deprotection with Boc-ethanolamine as raw material.An amphiphilic polymer(LA-PPEGMA-P(MMA-co-DAEMA)-CL)containing light sensitive crosslinker was synthesized by two-step atom transfer radical polymerization,acylation reaction between amino group and carboxyl group,and alkylation between tertiary amine and crosslinker.The structure of the polymer was characterized by FTIR and ^(1)H NMR.The critical micelle concentration of the polymer is 0.0629 mg/mL.The particle size of the micelles is 359.2 nm,and the Zeta potential is 27.9 mV.The micelles have photosensitivity,and the light sensitivity is the most significant at pH 6.5 and 7.4.
作者
赵鹏娟
归萌
徐宇
李泽鹏
冯文智
郝士军
余丽丽
ZHAO Pengjuan;GUI Meng;XU Yu;LI Zepeng;FENG Wenzhi;HAO Shijun;YU Lili(College of Pharmaceutical,Xi′an Medical University,Xi′an 710021,China;Institute of Medicine,Xi′an Medical University,Xi′an 710021,China)
出处
《化工科技》
CAS
2022年第2期31-37,共7页
Science & Technology in Chemical Industry
基金
国家级大学生创新创业项目(202011840018,202111840018)
陕西省大学生创新创业项目(S202011840018,S202111840018)
陕西省教育厅专项科研计划项目(20JK0892)
西安医学院大学生创新创业项目(121520018)
西安医学院校级科技创新团队项目(2021TD07)
西安医学院青年杰出人才配套项目(05041905)。
关键词
光敏感
胶束
半乳糖
Photo sensitive
Micelles
Galactose
作者简介
赵鹏娟(2001-),女,陕西咸阳人,西安医学院本科生,主要从事药物活性分子研究;通讯联系人:余丽丽(1983-),女,浙江衢州人,西安医学院教授,博士,主要从事活性分子和功能性高分子材料研究。
