摘要
目的 观察阿司匹林联合氯吡格雷治疗心肌梗死患者的临床疗效。方法 80例心肌梗死患者,按照随机数字表法分为观察组与对照组,各40例。观察组采用阿司匹林联合氯吡格雷治疗,对照组采用阿司匹林治疗。比较两组治疗前后的心功能指标、临床疗效、不良反应发生率、预后情况。结果 治疗后,两组左室射血分数(LVEF)均较治疗前升高,左室舒张末期内径(LVEDd)均较治疗前降低,且观察组LVEF(62.55±4.18)%高于对照组的(51.75±4.52)%, LVEDd(50.36±3.19)mm低于对照组的(56.26±3.36)mm,差异有统计学意义(P<0.05)。观察组治疗总有效率为95.0%,高于对照组的75.0%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后1年,观察组死亡率为5.0%(2/40),低于对照组的22.5%(9/40),差异有统计学意义(P<0.05)。结论 将阿司匹林联合氯吡格雷应用于心肌梗死治疗中,在改善患者心功能、降低死亡率方面有着突出效果,不增加不良反应,疗效确切,可予以推广。
Objective To observe the clinical efficacy of aspirin combined with clopidogrel on patients with myocardial infarction.Methods A total of 80 patients with myocardial infarction were divided into observation group and control group according to the random numerical table,with 40 cases in each group.The observation group was treated with aspirin combined with clopidogrel,and the control group was treated with aspirin.The cardiac function indexes before and after treatment,clinical efficacy,incidence of adverse reactions,and prognosis were compared between the two groups.Results After treatment,the left ventricular ejection fraction(LVEF)in both groups were increased compared with those before treatment in this group,and the left ventricular end-diastolic diameter(LVEDd)was decreased compared with before treatment in this group;the LVEF(62.55±4.18)%in the observation group was higher than(51.75±4.52)%in the control group,and the LVEDd(50.36±3.19)mm was lower than(56.26±3.36)mm in the control group;all the differences were statistically significant(P<0.05).The total effective rate of the observation group was 95.0%,which was higher than 75.0%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).1 year after treatment,the mortality rate in the observation group was 5.0%(2/40),which was lower than 22.5%(9/40)in the control group,and the difference was statistically significant(P<0.05).Conclusion Aspirin combined with clopidogrel has definite efficacy in the treatment of myocardial infarction,and has outstanding effects in improving patients'cardiac function and reducing mortality,without increasing adverse reactions,which can be promoted.
作者
张蕊
ZHANG Rui(Department of Internal Medicine,First Hospital of Xifeng County,Tieling 112499,China)
出处
《中国实用医药》
2022年第13期25-27,共3页
China Practical Medicine
关键词
阿司匹林
氯吡格雷
心肌梗死
心功能
Aspirin
Clopidogrel
Myocardial infarction
Cardiac function
