摘要
增生性瘢痕是常见的皮肤纤维化疾病,尽管目前已有手术切除、药物注射和放射治疗等治疗手段,但其治疗效果仍存在较大不确定性,且部分治疗方法甚至伴随较强副作用。随着对增生性瘢痕形成过程中免疫反应及相关细胞因子研究的不断深入,针对增生性瘢痕的免疫治疗策略也在逐步完善。白细胞介素10(IL-10)是白细胞家族的重要成员之一,在不同细胞有不同表达特点,主要通过调节增生性瘢痕中浸润的免疫细胞活性发挥免疫抑制作用。但在某些情况下,IL-10也具有免疫刺激作用。因此,揭示其在增生性瘢痕发生中的作用,对于更好地制定针对增生性瘢痕的免疫治疗策略和提高免疫治疗效果具有重要意义。
Hypertrophic scar is a common skin fibrosis disease.Currently,surgical resection,drug injection and radiotherapy were often used for treating it;however,limitations or adverse reactions still exist in these treatment.With the deepening understanding of immune response and related cytokines in the process of hypertrophic scar formation,the immunotherapy for hypertrophic scar is also gradually improved.Interleukin 10(IL-10)is an important member of the leukocyte family,which has different expression in different cells and exerts an immunosuppressive effect mainly through regulating the activity of immune cells infiltrated in hypertrophic scar.However,in some cases,IL-10 also exhibits an immunostimulatory effect.Therefore,its role in the formation of hypertrophic scar is critical for developing and improving the immunotherapy for hypertrophic scar.
作者
吴俊铮
宋雅娟
余州
宋保强
WU Junzheng;SONG Yajuan;YU Zhou;SONG Baoqiang(Xi’an Medical University,Xi'an 710068;Department of Plastic and Reconstructive Surgery,Xijing Hospital,Air Force Medical University,Xi'an 710032,China)
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2022年第4期368-373,共6页
Chinese Journal of Cellular and Molecular Immunology
基金
国家自然科学基金(81571906,82072182)
陕西省课题-一般项目-社会发展领域(2020SF-179)。
作者简介
吴俊铮(1997-),男,河南周口人,硕士研究生Tel:15565222365,E-mail:1042311810@qq.com;同为第一作者:宋雅娟;通讯作者:余州,E-mail:yz20080512@163.com;通讯作者:宋保强,E-mail:songbq1@163.com。
