摘要
目的评价PET/CT联合血清肿瘤标志物(NSE、CEA、CA125)测定在孤立性肺结节(SPN)良恶性鉴别中的诊断价值。方法对2018年1月至2019年12月期间在我院诊断为SPN的80例患者病例资料进行回顾性分析,所有患者均于10d内完成;F-FDG PET/CT扫描检查和肿瘤标志物(NSE、CEA、CA125)检测,以病理检查结果为“金标准”,利用受试者工作特征(ROC)曲线评价PET/CT、肿瘤标志物组合(简称TM)以及PET/CT联合TM三种方式鉴别SPN良恶性的诊断效能。结果病理结果证实,所有80例SPN患者中,肺癌57例,良性结节23例;以病理结果为“金标准”进行分组,结果显示恶性SP.N患者血清NSE、CEA水平明显高于良性.SPN组(P<005),CA125水平两组无明显差异(P>005),NSE、CEA高于临界值的.病例数在恶性SPN组比例明显高于良性SPN组(P<005);通过ROC曲线分.析,确定PET/CT鉴别SPN良恶性的最佳临界值为26,PET/CT、TM以及PET/CT联.合TM鉴.别SPN.的ROC曲线下面积(AUC)分别为0801、0752和0892,联合诊断方式.的ROC曲线下面积大于PET/CT,TM单项诊断(P<005),PET/C.T与TM单项诊断的AUC比较差异无统计学意义(P>005)。结论PET/CT联合肿瘤标志物组合检测能提高对SPN的诊断效能。
Objective To evaluate the differential diagnostic valueof PET/CT combined with serum tumor markers(Ns E, CEA, CA125) detection for benign and malignant solitary pulmonary nodules(s PN). Methods A retrospective analysis was performed on case data of 80 patients who were diagnosed with s PN in the hospital from January 2018 to December 2019. All patients underwent;F-FDG PET/CT scan tumor markers(Ns E, CEA, CA125) detection within 10 days. Taking pathological examination results as "golden standard", receiver operating characteristic(ROC) curves were performed to evaluate differential diagnostic value of PET/CT, tumor markers(TM) and PET/CT combined with TM for benign and malignant s PN. Results The pathological results confirmed that in the 80 s PN patients,there were 57 cases with lung cancer, and 23 cases with benign nodules. Taking pathological results as "golden standard", grouping was conducted. The results showed that levels of serum Ns E and CEA in malignant s PN group were significantly higher than those in benign s PN group(P<0.05).There was no significant difference in CA125 level between the two groups(P>0.05). The number of cases with Ns E and CEA higher than the critical value in the malignant s PN group was significantly higher than that in the benign s PN group(P<0.05). The further analysis by ROC curve determined that the best threshold value of PET/CT for identifying benign and malignant s PN was 2.6. The areas under the ROC curve(AUC) of PET/CT, TM and PET/CT combined TM for identifying s PN were 0.801, 0.752, and 0.892, respectively. The AUC of combined diagnosis was larger than that of PET/CT, TM single diagnosis(P<0.05), while the difference between PET/CT and TM was not statistically significant(P>0.05). Conclusion PET/CT combined with TM detection can improve diagnostic efficiency for s PN.
作者
喻晖
齐佳
YU Hui;QI Jia(Department of Nuclear Medicine,Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science,Xiangyang 441021,Hubei Province,China)
出处
《中国CT和MRI杂志》
2022年第7期61-63,共3页
Chinese Journal of CT and MRI
作者简介
第一作者:喻晖,女,主治医生,主要研究方向:PET-CT,ECT影像诊断,核素治疗。E-mail:1450444877@qq.com;通讯作者:齐佳,女,初级医师,主要研究方向:PET-CT,ECT影像诊断,核素治疗。E-mail:vl5ioy8@163.com。
