摘要
基于生物粘合剂贻贝粘附蛋白的特性,进行人工粘合材料的结构设计,将具有很强修饰性的聚氨酯片段与功能粘合单元邻二酚片段进行有效接合,通过仿生合成得到一种新型粘合材料。对所合成粘合材料进行结构表征、线路优化、热稳定性与细胞毒性实验,初步评价该仿生粘合材料在生命体环境中的安全性和适用性。结果显示,仿生合成手段能够保证该粘合材料的生物亲合性能,同时,合成线路的优化也增强了该粘合材料的可修饰性,使其具有良好的生物学与医学应用前景。
Inspired by the bio-adhesive characteristics of mussel adhesive protein, a biomimetic MAP adhesive material was designed and synthesized by incorporating the adhesive unit o-diphenol to polyurethane. Structural characterization, synthetic optimization, thermal stability and cytotoxicity were carried out to evaluate the safety and applicability of the synthesized adhesive material in living organisms. Experimental results indicated that the bio-affinity of this adhesive material was guaranteed by the biomimetic synthesis and its chemical modifications were also enhanced through the synthetic optimization, of fering the biomimetic MAP adhesive material full of possibilities in its future biological and medical applications.
作者
成昭
程诗雅
尉祎雯
冯凯茵
张雪娇
CHENG Zhao;CHENG Shi-ya;WEI Yi-wen;FENG Kai-yin;ZHANG Xue-jiao(School of Pharmacy,Xi’an Medical University,Xi’an 710021,Shaanxi,China)
出处
《合成材料老化与应用》
2022年第3期68-70,16,共4页
Synthetic Materials Aging and Application
基金
陕西省科技厅自然科学基础研究计划(2022JM-542)
陕西省教育厅自然科学项目(20JK0902)
西安医学院科研项目(2020DOC32)。
关键词
粘合材料
仿生合成
优化
细胞毒性
adhesive material
biomimetic synthesis
optimization
cytotoxicity
作者简介
成昭,副教授,博士,主要从事功能材料合成及分析研究。
