摘要
随着社会和科技水平的进步,人群寿命普遍延长,高龄人群增加,老年人健康状态备受关注。痴呆是困扰老年人群的重要疾病,由于缺乏有效诊断和治疗措施,缓解和逆转痴呆是目前老年疾病的重要研究方向之一。它与神经系统衰老所致神经退行性改变的因果关系备受争议,但二者之间显示出明确的相关性。年龄是痴呆发生的重要危险因素,衰老过程中神经元代谢、结构、功能状态及微环境变化与痴呆发生发展密切相关。为此,本文对神经元衰老在痴呆发生发展的研究现状与进展作一述评。
With the development of society and technology,the life expectancy of the population has been generally extended,the aging popolation has been increasing,and the health status of the elderly arouses great concern in society.Due to the lack of effective diagnosis and treatment procedures,alleviating and reversing dementia have been one of the important directions in aging diseases.The causal relationship of dementia to neurodegenerative changes in the aging nervous system is controversial,but there is a clear correlation between the two.Changes in neuronal metabolism,structure,functional status and microenvironment during aging are closely related to the occurrence and development of dementia,and age is an important risk factor for dementia.Dementia is one of the important diseases afflicting the elderly population.
作者
周良学
周文武
ZHOU Liangxue;ZHOU Wenwu(Department of Neurosurgery,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《西部医学》
2022年第6期781-784,共4页
Medical Journal of West China
基金
国家自然科学基金面上项目(81772693)。
关键词
痴呆
衰老
神经元
神经微环境
免疫损伤
Dementia
Aging
Neurons
Neural microenvironment
Immune damage
作者简介
周良学,教授,博士生导师,中华医学会神经外科分会第8届委员会青年委员会委员兼秘书,中国医师协会内镜医师分会委员,中国人体健康科技促进会临床神经科学技术转化专业委员会常委,四川省神经外科专委会青年委员会前任副主任委员,《BrainResearch》《西部医学》等杂志的审稿专家。E-mail:zhlx111@163.com。
