摘要
目的观察赖氨葡锌在轮状病毒肠炎伴良性惊厥患儿中的应用效果。方法选取2019年11月至2020年11月宜春学院第二附属医院收治的80例轮状病毒肠炎伴良性惊厥患儿作为研究对象,按照随机数字表法分为观察组和对照组,每组各40例。对照组给予利巴韦林单药治疗,观察组给予利巴韦林联合赖氨葡锌治疗。比较两组患儿治疗1周后的临床疗效及不良反应情况,记录随访1年期间两组患儿的复发及转化癫痫情况,同时比较两组患儿治疗前后的炎症因子水平变化。结果治疗后,观察组患儿的治疗总有效率为95.00%,高于对照组的77.50%,差异有统计学意义(P<0.05);观察组患儿的呕吐、腹泻及发热消失时间,脱水纠正时间,粪便成型时间和住院时间均短于对照组,惊厥次数少于对照组,差异有统计学意义(P<0.05);治疗后,观察组患儿的CD4^(+)水平高于对照组,白介素-6(IL-6)、肿瘤坏死因子(TNF-α)水平低于对照组,差异有统计学意义(P<0.05);两组患儿的复发率比较,差异无统计学意义(P>0.05),且均无转化癫痫者;两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论赖氨葡锌能有效降低轮状病毒肠炎伴良性惊厥患儿的炎症因子水平,增强患儿机体抵抗力,提高临床治疗效果,改善预后。
Objective To observe the application effect of Lysine Zinc Gluconate in children with rotavirus enteritis and benign convulsions.Methods A total of 80 children with rotavirus enteritis and benign convulsions who were admitted to the Second Affiliated Hospital of Yichun University from November 2019 to November 2020 were selected as the research objects,and they were divided into the observation group and the control group according to random number table method,with 40 cases in each group.The control group was treated with Ribavirin,and the observation group was treated with Ribavirin combined with Lysine Zinc Gluconate.The clinical efficacy and adverse reactions after 1 week of treatment of the two groups were compared between the two groups.The recurrence and transformation of epilepsy of the two groups were recorded during one-year follow-up.At the same time,the changes of levels of inflammatory factors before and after treatment were compared between the two groups.Results After treatment,The total effective rate of the observation group was 95.00%,which was higher than 77.50%of the control group,the difference was statistically significant(P<0.05).The abatement time of vomiting,diarrhea and fever,dehydration correction time,stool formation time and hospital stay of the observation group were significantly shorter than those of the control group,and the number of convulsions of the observation group was significantly smaller than that of the control group,the differences were statistically significant(P<0.05).After treatment,the level of CD4^(+)in the observation group was significantly higher than that in the control group,the levels of interleukin-6(IL-6)and tumor necrosis factorα(TNF-α)of the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the recurrence rate between the two groups(P>0.05),and there was no patients developing into epilepsy).There was no significant difference in the total incidence of adverse reactions between the two groups(P<0.05).Conclusion Lysine Zinc Gluconate can effectively reduce the level of inflammatory factors in children with rotavirus enteritis with benign convulsion,enhance the body resistance of children,improve the clinical treatment effect and the prognosis.
作者
邓添
刘祎
DENG Tian;LIU Yi(Department of Pediatrics,the Second Affiliated Hospital of Yichun University,Jiangxi Province,Yichun336000,China)
出处
《中国当代医药》
CAS
2022年第15期84-87,共4页
China Modern Medicine
基金
江西省卫生健康委科技计划项目(202212704)。
关键词
赖氨葡锌
轮状病毒肠炎
良性惊厥
预后效果
Lysine Zinc Gluconate
Rotavirus enteritis
Benign convulsion
Prognosis effect
作者简介
邓添(1984-),女,湖南湘乡人,副主任医师。
