摘要
目的探讨在进行小儿糖尿病的治疗时采用二甲双胍联合胰岛素用药治疗的临床效果。方法选择2020年8月—2021年8月该院收治的小儿糖尿病患儿78例。将患儿按照入院顺序进行编号,将1~39号患儿纳入对照组,采用单一甘精胰岛素治疗;40~78号患儿纳入研究组,采用二甲双胍+甘精胰岛素联合用药治疗,对比患儿血糖水平、治疗有效率、胰岛素抵抗指数、胰岛β细胞功能、胰岛素敏感指数、血脂水平及生活质量评分。结果研究组患儿空腹血糖、餐后2 h血糖与糖化血红蛋白水平显著降低且均低于对照组,差异有统计学意义(P<0.05);研究组患儿治疗有效率较对照组高,差异有统计学意义(P<0.05);研究组患儿胰岛素抵抗指数显著降低且低于对照组,胰岛β细胞功能与胰岛素敏感指数显著升高且高于对照组,差异有统计学意义(P<0.05);研究组患儿三酰甘油、总胆固醇及低密度脂蛋白胆固醇水平均显著降低且均低于对照组,高密度脂蛋白胆固醇显著升高且高于对照组,差异有统计学意义(P<0.05);研究组患儿SF-36评分中各项评分均高于对照组,差异有统计学意义(P<0.05)。结论在治疗小儿糖尿病患儿时采取二甲双胍联合胰岛素联合用药治疗可进一步提升血糖与血脂控制效果,改善胰岛β细胞功能,提高患儿的生活质量,建议推广应用。
Objective To investigate the clinical effect of metformin combined with insulin in the treatment of children with diabetes.Methods A total of 78 children with diabetes who were admitted to the hospital from August 2020 to August 2021 were selected.The children were numbered according to the order of admission,and the children 1-39 were included in the control group and treated with insulin glargine alone;the children 40-78 were included in the study group and treated with the combination of metformin+insulin glargine.Blood glucose level,treatment response rate,insulin resistance index,pancreaticβ-cell function,insulin sensitivity index,blood lipid level and quality of life score.Results The levels of fasting blood glucose,2-hour postprandial blood glucose and glycosylated hemoglobin in the study group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).The treatment effective rate of the children in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).The insulin resistance index of the children in the study group was significantly lower and lower than that in the control group,while the isletβ-cell function and insulin sensitivity index were significantly higher and higher than those in the control group,the difference was statistically significant(P<0.05).The levels of triacylglycerol,total cholesterol and low-density lipoprotein cholesterol in the study group were significantly lower and lower than those in the control group,while the high-density lipoprotein cholesterol was significantly higher and higher than that in the control group,the difference was statistically significant(P<0.05).The SF-36 scores of the children in the study group were higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of children with diabetes,the combination of metformin and insulin can further improve the control effect of blood glucose and blood lipids,improve the function of isletβcells,and improve the quality of life of children.It is recommended to popularize and apply.
作者
贾旖旎
顾梦迨
JIA Yini;GU Mengyi(Department of Pharmacy,Wuxi Children's Hospital,Wuxi,Jiangsu Province,214000 China)
出处
《糖尿病新世界》
2022年第9期63-66,70,共5页
Diabetes New World Magazine
关键词
小儿
糖尿病
二甲双胍
甘精胰岛素
血糖水平
生活质量
Children
Diabetes
Metformin
Insulin glargine
Blood glucose level
Quality of life
作者简介
贾旖旎(1992-),女,本科,初级药师,研究方向为药学。
