摘要
目的通过测定血透患者血清Klotho水平,探讨其与钙磷代谢、营养指标的关系,了解血清Klotho水平对血透患者预后的影响。方法选取2018年6月—2021年6月在该院进行血液透析治疗的终末期肾脏疾病患者130例进行临床及随访研究,纳入观察组,另选取相同时间段在该院进行体检的100名健康志愿者纳入对照组。比较两组血清Klotho水平、钙(Ca)、磷(P)及MQSGA评分,采用Pearson相关性分析血清Klotho水平与钙Ca、P、MQSGA评分相关性。根据观察组130例患者血清Klotho水平中位数17.04(10.03,23.38)分为低血清Klotho组和高血清Klotho组,比较两组预后情况,分析两组血清Klotho水平与预后相关性。结果观察组血清Klotho水平(16.71±3.31)、Ca(2.17±0.25)mmol/L、P(1.89±0.57)mmol/L均低于对照组,MQSGA评分(21.09±2.16)分高于对照组,两组差异有统计学意义(t=13.958、5.323、2.412、31.331,P<0.05);血清Klotho水平与Ca、P呈正相关,与MQSGA评分呈负相关(P<0.05)。低血清Klotho组存活率明显高于高血清Klotho组,两组差异有统计学意义(P<0.05);两组血清Klotho水平与预后呈正相关,且低血清Klotho组的相关性强于高血清Klotho组(P<0.05)。结论血透患者血清klotho水平与钙磷代谢、营养指标密切相关,血清Klotho水平可有效预测患者预后质量价值。
Objective To investigate the relationship between serum Klotho level and calcium and phosphorus metabolism and nutritional indexes in hemodialysis patients,and to understand the influence of serum Klotho level on the prognosis of hemodialysis patients.Methods From June 2018 to June 2021,130 patients with end-stage renal disease who underwent hemodialysis treatment in the hospital were selected for clinical and follow-up studies,and were regarded as the observation group.Another 100 healthy volunteers who underwent physical examination in the hospital during the same time period were selected as the control group.The serum Klotho levels,calcium(Ca),phosphorus(P)and MQSGA scores were compared between the two groups.Pearson correlation was used to analyze the correlation between serum Klotho Level and calcium Ca,P and MQSGA scores.130 patients in the observation group were divided into a low serum Klotho group and a high serum Klotho group according to the median serum Klotho level of patients,which was 17.04(10.03,23.38).The prognosis of the two groups was compared.Analyze the correlation between serum klotho levels and prognosis in the two groups. Results The serum Klotho level (16.71±3.31), Ca (2.17±0.25) mmol/L and P (1.89±0.57) mmol/L in the observation group were lower than those in the control group. The MQSGA score (21.09±2.16) points was higher than that of the control group, and the difference was statistically significant (t=13.958, 5.323, 2.412, 31.331, P<0.05). Serum Klotho level was positively correlated with Ca and P, and negatively correlated with MQSGA score (P<0.05). The survival rate of the low serum Klotho group was significantly higher than that of the high serum Klotho group, and the difference was statistically significant (P<0.05). The serum Klotho level in both groups was positively correlated with prognosis, and the correlation in the low serum Klotho group was stronger than that in the high serum Klotho group (P<0.05). Conclusion The serum klotho level of hemodialysis patients is closely related to calcium and phosphorus metabolism and nutritional indicators, and the serum Klotho level can effectively predict the prognostic quality value of patients.
作者
牛福坤
胡范玲
郭淑霞
庄炎
赵慧
孙娟娟
武凤玉
NIU Fukun;HU Fanling;GUO Shuxia;ZHUANG Yan;ZHAO Hui;SUN Juanjuan;WU Fengyu(Department of Nephrology,Linyi Central Hospital,Linyi,Shandong Province,276400 China)
出处
《系统医学》
2022年第7期26-30,共5页
Systems Medicine
关键词
血透患者
血清Klotho水平
钙磷代谢
营养指标
预后
Hemodialysis patients
Serum Klotho level
Calcium and phosphorus metabolism
Nutritional indicators
Prognosis
作者简介
牛福坤(1985-),男,硕士,主治医师,研究方向为慢性肾衰竭的防治。;通信作者:胡范玲(1985-),女,本科,主治医师,研究方向为血液透析,E-mail:hfllingling@126.com。
