摘要
隐孢子虫病(Cryptosporidiosis)是由隐孢子虫(Cryptosporidium)寄生于人和动物胃肠道上皮细胞内并引起以腹泻为特征的一种重要的机会性原虫病,该病严重威胁人类健康,给畜牧养殖业造成巨大的经济损失。有研究显示,隐孢子虫需借助顶端复合体分泌的蛋白分子入侵宿主细胞,因此,阐明隐孢子虫入侵相关蛋白分子的作用机制具有重要意义。论文主要对磷脂酶A2、Cp2、Cpa135、CpSUB和CpMuc等5种隐孢子虫入侵相关蛋白分子的结构和功能进行综述,以期为研究隐孢子虫入侵机制和抗隐孢子虫药物与疫苗的研究提供参考。
Cryptosporidiosis is an important opportunistic pathogenic protozoosis,and diarrhea is its typical characteristic caused by Cryptosporidium that parasitizes in the gastrointestinal epithelial cells of humans and animals.Cryptosporidiosis is a serious threat to human health and has caused huge economic losses to animal husbandry.Studies have shown that the protein molecules secreted by the apical complex are required during the invasion of host cells,thus it is of great significance to elucidate the mechanism of action of invasion-related proteins in Cryptosporidium.This paper reviewed the structure and function of phospholipase A2,Cp2,Cpa135,CpSUB and CpMuc associated with Cryptosporidium invasion,in order to lay a theoretical foundation for studying the Cryptosporidium invasion mechanism and anti-Cryptosporidium medicine and vaccine.
作者
孙露露
谢褔杰
李娟锋
边啸坤
王荣军
SUN Lu-lu;XIE Fu-jie;LI Juan-feng;BIAN Xiao-kun;WANG Rong-jun(College of Veterinary Medicine,Henan Agricultural University,Zhengzhou,Henan,450046,China)
出处
《动物医学进展》
北大核心
2022年第6期91-94,共4页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(U2004155,31672548)。
关键词
隐孢子虫病
隐孢子虫
入侵相关蛋白
作用机制
Cryptosporidiosis
Cryptosporidium
invasion-related protein
mechanism of action
作者简介
孙露露(1996-),女,河南周口人,硕士研究生,主要从事兽医寄生虫学研究;通讯作者:王荣军。
