摘要
结核性胸膜炎(TP)是肺外结核的常见表现形式,通常由结核分枝杆菌(MTB)感染胸膜所致,胸膜腔中会积累大量的免疫活性细胞并伴随细胞因子的释放,其中最为关键的是γ干扰素(IFN-γ)。IFN-γ既是宿主保护性免疫细胞分泌的重要因子,也是抗MTB免疫反应中特有的促炎性细胞因子环境标志物。本文对IFN-γ依赖性免疫应答在TP发病机制、诊断及治疗监测中的研究进展进行综述,以期为TP的诊治提供新的思路。
Tuberculous pleuritis(TP)is a common manifestation of extrapulmonary tuberculosis,which is usually caused by Mycobacterium tuberculosis(MTB)infection of the pleura.A large number of immunocompetent cells are accumulated in the pleural cavity,accompanied by the release of cytokines,among which interferon-gamma(IFN-γ)is the most important.IFN-γis not only an important factor secreted by the host protective immune cells,but also a specific environmental marker of pro-inflammatory cytokines in anti-MTB immune response.This article reviewed the research progress of IFN-γ-dependent immune response in the pathogenesis,diagnosis and therapeutic monitoring of TP in order to provide new ideas for the diagnosis and treatment of TP.
作者
冯小红
张璐璐
薛庆亮
FENG Xiaohong;ZHANG Lulu;XUE Qingliang(Department of Respiratory and Critical Care Medicine,the 940th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Aarmy,Lanzhou,Gansu,730050;School of Clinical Medicine of Ningxia Medical University,Yinchuan,Ningxia,750004)
出处
《实用临床医药杂志》
CAS
2022年第9期139-143,共5页
Journal of Clinical Medicine in Practice
关键词
Γ干扰素
细胞免疫
炎症
结核性胸膜炎
结核分枝杆菌
interferon-gamma
cellular immunity
inflammation
tuberculous pleuritis
Mycobacterium tuberculosis
作者简介
通信作者:薛庆亮,E-mail:xql0121@sohu.com。
