摘要
目的探讨结肠镜检查联合CEA、CA242在结肠息肉癌变诊断中的作用及结肠息肉癌变相关因素分析。方法选取2019年6月至2021年6月于本院收治的结肠息肉患者106例,根据病理学资料分为腺瘤性息肉组(n=83)和非腺瘤性息肉组(n=23)。比较两组患者的临床资料、病变直径、病变数量以及CEA和CA242的表达水平,并分析其与结肠癌变的相关性。结果两组年龄、病理类型、CEA、CA242水平相比,差异有统计学意义(P<0.05),腺瘤性息肉组年龄、腺瘤型比例以及血清CEA、CA242水平均显著高于非腺瘤性息肉组(P<0.05)。多因素分析显示,年龄、病理类型、CEA和CA242是结肠癌的独立影响因素。ROC曲线对病理类型、CEA和CA242及联合检测诊断结肠息肉癌变效能进行分析,病理类型、CEA和CA242检测AUC分别为0.732、0.697、0.713,联合检测AUC为0.821,高于单独检测的AUC值。结论病理类型与结肠癌相关因素CEA和CA242的表达水平有关,各指标的联合检测有望为结肠息肉和结肠癌的诊断和鉴别诊断提供新的方法。
Objective To investigate the role of colonoscopy combined with CEA and CA242 in the diagnosis of colon polyp carcinogenesis and the analysis of related factors of colon polyp carcinogenesis.Methods 106 patients with colonic polyps admitted to our hospital from June 2019 to June 2021 were selected and divided into adenomatous polyp group(n=83)and non-adenomatous polyp group(n=23)according to pathological data.The clinical data,lesion diameter,lesion number and expression levels of CEA and CA242 were compared between the two groups,and their correlation with colon cancer was analyzed.Results The differences in age,pathological type,CEA and CA242 levels between the two groups were statistically significant(P<0.05).The age,adenoma type ratio,and serum CEA and CA242 levels in the adenomatous polyp group were significantly higher than those in the non-adenomatous polyp group(P<0.05).Multivariate analysis showed that age,pathological type,CEA and CA242 were independent influencing factors of colon cancer.ROC curve was used to analyze the pathological type,CEA and CA242,and the efficacy of combined detection in the diagnosis of colorectal polyps.The AUCs of pathological type,CEA and CA242 were 0.732,0.697,and 0.713,respectively.The AUC of combined detection was 0.821,which was higher than that of separate detection.Conclusion The pathological type was related to the expression levels of CEA and CA242.The combined detection of each index is expected to provide a new method for the diagnosis and differential diagnosis of colon polyps and colon cancer.
作者
王国杰
翟得欣
任洋洋
谢景军
WANG Guo-jie;ZHAI De-xin;REN Yang-yang;XIE Jing-jun(Department of Gastroenterology,Zhengzhou Ruixiang Hospital,Xingyang 450100,Henan Province,China;Department of Clinical Laboratory,Zhengzhou Ruixiang Hospital,Xingyang 450100,Henan Province,China;Department of General Surgery,Henan Armed Police Corps Hospital,Zhengzhou 450052,Henan Province,China)
出处
《罕少疾病杂志》
2022年第6期89-91,101,共4页
Journal of Rare and Uncommon Diseases
作者简介
通讯作者:第一作者:王国杰,男,主治医师,主要研究方向:消化内科及消化内镜。E-mail:wgj740321@163.com。
