摘要
目的探讨快速眼动睡眠期行为障碍(RBD)发病至出现帕金森病运动症状的时间间隔与帕金森病临床特征的相关性。方法纳入2019年9月至2021年12月天津市环湖医院收治的123例帕金森病患者,分为帕金森病伴很可能的RBD组(伴RBD组,41例)和帕金森病不伴很可能的RBD组(不伴RBD组,82例),采用Hoehn-Yahr分期进行帕金森病疾病分级,统一帕金森病评价量表第三部分(UPDRSⅢ)评价运动症状,简易智能状态检查量表(MMSE)和蒙特利尔认知评价量表(MoCA)评价认知功能,汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评价焦虑和抑郁症状严重程度,帕金森病睡眠量表(PDSS)评价睡眠障碍,非运动症状量表(NMSS)评价总体非运动症状严重程度,39项帕金森病调查表(PDQ-39)评价生活质量。Spearman秩相关分析探究RBD发病至出现帕金森病运动症状的时间间隔与其临床特征的相关性。结果伴RBD组患者UPDRSⅢ评分(t=-2.703,P=0.008)和NMSS评分(t=-2.176,P=0.032)高于不伴RBD组;Spearman秩相关分析显示,RBD发病至出现帕金森病运动症状的时间间隔仅与NMSS评分呈正相关(r_(s)=0.547,P=0.001)。结论伴RBD的帕金森病患者存在较严重的运动症状和非运动症状,且RBD出现越早、非运动症状越严重。
Objective To study the correlation between the time from rapid eye movement sleep behavior disorder(RBD)to disease onset and the clinical characteristics of Parkinson’s disease(PD).M ethodsA total of 123 PD patients were recruited from Tianjin Huanhu Hospital between September2019 and December 2021.All participants were divided into the group with RBD(41 cases)and the group without RBD(82 cases)according to the probable RBD criteria.Hoehn-Yahr staging was used to evaluate PD grade.Unified Parkinson’s Disease Rating Scale Ⅲ(UPDRS Ⅲ)was used to evaluate the motor function of PD.Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA),Hamilton Anxiety Rating Scale(HAMA)and Hamilton Depression Rating Scale(HAMD),Parkinson’s Disease Sleep Scale(PDSS),and Non-Motor Symptom Scale(NMSS)were used to evaluate cognitive function,anxiety,depression,sleep and total non-motor symptoms.The life quality of patients was evaluated by 39-Item Parkinson’s Disease Questionnaire(PDQ-39).Spearman rank correlation analysis was used to explore the correlation between the time from RBD to disease onset and clinical characteristics in PD.Results UPDRSⅢ(t=-2.703,P=0.008)and NMSS(t=-2.176,P=0.032)scores of PD with RBD group were higher than those of the PD without RBD group.The time from the RBD to the onset of PD was positively correlated with NMSS score(r_(s)=0.547,P=0.001).Conclusions The motor and non-motor symptoms in PD patients with RBD are more severe than those of patients without RBD.Early onset of RBD in prodromal period may indicates more severe non-motor symptoms in future.
作者
李欣
任宁
王敏
陈学姣
陈蕾
LI Xin;REN Ning;WANG Min;CHEN Xue-jiao;CHEN Lei(Department of Neurology,Tianjin Huanhu Hospital/Tianjin Key Laboratory of Cerebral Vascular and JS eur ode generative Diseases,Tianjin 300350,China)
出处
《中国现代神经疾病杂志》
CAS
北大核心
2022年第3期168-172,共5页
Chinese Journal of Contemporary Neurology and Neurosurgery
基金
天津市医学重点学科(专科)建设项目。
作者简介
李欣,对本文有同等贡献;任宁,对本文有同等贡献;通讯作者:陈蕾,Email:halo1881@163.com。
