摘要
目的探讨普拉克索联合多巴丝肼治疗老年帕金森病(Parkinson’s disease,PD)的临床效果。方法选取盘锦市中心医院2019—2020年收治的老年PD患者100例,随机分为单药组和联合组各50例。单药组采用多巴丝肼进行治疗,联合组加用普拉克索进行治疗,两组均治疗6个月后评价疗效。比较两组治疗后的病情、自我效能和神经因子水平。结果干预6个月后,联合组统一帕金森病评定量表各部分评分及总分均低于单药组,差异有统计学意义(P<0.05);联合组慢性病管理自我效能感量表各部分评分及总分均高于单药组,差异有统计学意义(P<0.05);联合组中枢神经特异性蛋白-β低于单药组,而脑源性神经营养因子和5-羟色胺高于单药组,差异有统计学意义(P<0.05)。结论普拉克索联合多巴丝肼治疗老年PD,可以进一步缓解患者的临床症状,提高自我效能和改善神经因子水平。
Objective To investigate the clinical effect of pramipexole combined with levodopa/benserazide in the treatment of senile Parkinson’s disease(PD).Methods A total of 100 elderly PD patients treated in Panjin Central Hospital from 2019 to 2020 were randomly divided into single drug group and combined group.The single drug group was treated with Levodopa and Lenserazide Hydrochlo-ride and the combined group was treated with pramipexole+Levodopa and Lenserazide Hydrochlo-ride.The curative effects,self-efficacy and nerve factor levels of the two groups were evaluated after 6 months of treatment.Results After 6 months of intervention,the each score and total score of unified Parkinson’s disease rating scale in the combined group were significantly lower than those in the single drug group(P<0.05).The scores of each part and total score of chronic disease management self-efficacy scale in the combined group were significantly higher than those in the single drug group(P<0.05).The level of central nerve specific protein-βin the combined group was significantly lower than that in the single drug group,while the level of brain derived neurotrophic factor and 5-hydroxytryptamine in combined group were significantly higher than those in the single drug group(P<0.05).Conclusion Pramipexole combined with levodopa/benserazide in the treatment of elderly PD can further alleviate the clinical symptoms,improve self-efficacy,and improve the level of nerve factors.
作者
李崇峰
李卓
刘嘉俊
赵颖
沈慈
LI Chongfeng;LI Zhuo;LIU Jiajun;ZHAO Ying;SHEN Ci(Second Department of Neurology,Panjin Central Hospital,,Panjin 124000,Liaoning Province,China)
出处
《中国实用乡村医生杂志》
2022年第3期27-29,共3页
Chinese Practical Journal of Rural Doctor
关键词
帕金森病
老年
普拉克索
多巴丝肼
自我效能
神经因子
Parkinson’s Disease
Old Age
Pramipexole
Levodopa and Lenserazide Hydrochlo-ride
Self Efficacy
Nerve Factor
