摘要
目的探讨重症呼吸衰竭(RF)患者给予右美托咪定适度镇静联合呼吸机无创辅助通气治疗对肺功能、血气指标及预后的影响。方法选取2019年6月至2021年12月在周口市第一人民医院治疗的重症RF患者88例作为研究对象,按照随机数字表法分成观察组(44例)和对照组(44例),对照组给予呼吸机无创通气治疗,观察组给予右美托咪定适度镇静联合呼吸机无创辅助通气治疗,比较两组患者肺通气功能、血气指标及预后。结果观察组治疗有效率较高于对照组,差异有统计学意义(P<0.05);两组治疗后第1 s用力呼气容积(FEV1)及最大通气量(MVV)提高,差异有统计学意义(P<0.05),用力肺活量(FVC)降低,差异有统计学意义(P<0.05),观察组FEV1、MVV较对照组更高,FVC更低,差异有统计学意义(P<0.05);两组治疗后动脉血氧分压(PaO_(2))、血氧饱和度(SaO_(2))提高,动脉二氧化碳分压(PaCO_(2))降低,差异有统计学意义(P<0.05),观察组PaO_(2)、SaO_(2)较对照组更高,PaCO_(2)更低,差异有统计学意义(P<0.05);观察组不良反应发生率及死亡率较对照组更低,差异有统计学意义(P<0.05)。结论重症RF患者给予右美托咪定适度镇静联合呼吸机无创辅助通气治疗,可提高临床疗效,改善肺功能、血气指标及预后。
Objective To investigate the effect of moderate sedation with dexmedetomidine combined with ventilator noninvasive assisted ventilation on pulmonary function,blood gas indexes and prognosis in patients with severe respiratory failure(RF).Methods A total of 88 patients with severe RF who were treated in Zhoukou First People’s Hospital from June 2019 to December 2021 were selected as the research objects,and they were divided into the observation group(44 cases)and the control group(44 cases)according to the random number table method.The control group was given non-invasive ventilation with ventilator,and the observation group was given moderate sedation with dexmedetomidine combined with non-invasive assisted ventilation with ventilator.The pulmonary ventilation function,blood gas indexes and prognosis of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).The forced expiratory volume at 1s(FEV1)and maximum ventilation volume(MVV)after treatment in the two groups were significantly increased(P<0.05),and the forced vital capacity(FVC)was significantly decreased(P<0.05),FEV1 and MVV in the observation group were significantly higher than those in the control group(P<0.05),and FVC was significantly lower(P<0.05).After treatment,the arterial partial pressure of oxygen(PaO_(2))and blood oxygen saturation(SaO_(2))in the two groups were significantly increased(P<0.05),and the arterial partial pressure of carbon dioxide(PaCO_(2))was significantly decreased(P<0.05),PaO_(2) and SaO_(2) in the observation group were significantly higher than those in the control group(P<0.05),and PaCO_(2) was significantly lower(P<0.05).The incidence of adverse reactions and mortality in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Moderate sedation with dexmedetomidine combined with ventilator non-invasive assisted ventilation in severe RF patients can improve clinical efficacy,improve lung function,blood gas indexes and prognosis.
作者
殷永超
YIN Yongchao(Department of Respiratory and Critical Care Medicine,First People’s Hospital of Zhoukou City,Zhoukou Henan 466700,China)
出处
《临床研究》
2022年第5期76-79,共4页
Clinical Research
关键词
右美托咪定
适度镇静
呼吸机无创辅助通气
重症呼吸衰竭
肺功能
血气指标
预后
dexmedetomidine
moderate sedation
ventilator non-invasive assisted ventilation
severe respiratory failure
pulmonary function
blood gas indicators
prognosis
作者简介
殷永超(1968-),男,汉族,河南周口人,副主任医师,本科。研究方向:呼吸内科方面。
