摘要
目的:总结和分析冯明清治疗胃脘痛的用药规律。方法:收集整理其治疗胃脘痛的有效门诊处方共92个,涉及中药181味,统计处方中单味中药的性、味、归经、药物功效、使用频次,并运用聚类分析法和关联分析法总结其功效作用。结果:冯明清治疗胃脘痛常用药物为甘草、半夏、厚朴、陈皮等药物,药性以温为主,平、寒次之;药味以甘为主,辛、苦次之;药物归经以胃经为主,脾经、心经、肾经、肺经次之。聚类方结果分析:聚类分析得到4个聚类方,分别是:聚类1:半夏、陈皮、厚朴、白前、枳实;聚类2:黄连、黄芩、竹茹;聚类3:北沙参、麦冬、地黄、知母;聚类4:黄芪、白术、茯苓、当归、党参、延胡索、赤芍。关联结果分析:高频药物组合多为化痰理气与清热解毒、活血化瘀之品的组合,选择药物组合多为理气、清热、化痰、化瘀之品。结论:冯明清治疗胃脘痛以抓主证、重次证、顾兼证为诊疗思想,治疗时多选理气、清热、化痰、化瘀之品。
Objective:To summarize and analyze the medication rules of Feng Mingqing in the treatment of epigastric pain.Methods:A total of 92 effective outpatient prescriptions for the treatment of epigastric pain were collected and sorted,involving 181 Chinese medicines.The properties,taste,meridian distribution and drug efficacy,and frequency of single drugs in the prescriptions were counted,and cluster analysis and correlation analysis were used to summarize its efficacy.Results:Feng Mingqing′s commonly used drugs for the treatment of epigastric pain were Gancao(Radix Glycyrrhizae),Banxia(Rhizoma Pinelliae),Houpu(Cortex Magnoliae Officinalis),Chenpi(Pericarpium Citri Reticulatae)and other drugs The medicinal properties are mainly warm,followed by plain and cold.The medicinal taste is mainly sweet,followed by pungent and bitter.The main meridian distribution is the Stomach meridian,followed by the Spleen meridian,Heart meridian,Kidney meridian,and Lung meridian.Clustering prescription result analysis:Cluster analysis obtained 4 clustering prescriptions,namely:Cluster 1:Banxia(Rhizoma Pinelliae),Chenpi(Pericarpium Citri Reticulatae),Houpu(Cortex Magnoliae Officinalis),Baiqian(Rhizoma Cynanchi Stauntonii),Zhishi(Fructus Aurantii Immaturus);Cluster 2:Huanglian(Rhizoma Coptidis),Huangqin(Radix Scutellariae),Zhuru(Caulis Bambusae in Taenia);Clustering 3:Beishahsen(Radix Glehniae),Maidong(Radix Ophiopogonis),Dihuang(Rehmannia),Zhimu(Rhizoma Anemarrhenae);Cluster 4:Huangqi(Radix Astragali seu Hedysari),Baishu(Rhizoma Atractylodis Macrocephalae),Fuling(Poria),Danggui(Radix Angelicae Sinensis),Dangshen(Radix Codonopsis),Yuanhu(Rhizoma Corydalis),Chishao(Radix Paeoniae Rubra).Analysis of correlation results:high-frequency drug combination is mostly the combination of regulating Qi-flowing for eliminating Phlegm,clearing Heat-toxicity,promoting Blood circulation for removing Blood stasis products,and the selected drug combination is mostly Qi-regulating,Heat-clearing,Phlegm-resolving,and Blood-stasis-removing products.Conclusion:Feng Mingqing′s diagnosis and treatment thought of epigastric pain is focused on the main syndrome,with the secondary syndrome being paid attention,and accompanying symptoms being takn into account.In clinical treatment,drugs that can regulate Qi,clear Heat,resolve Phlegm,and remove Blood stasis are often selected.
作者
张超
谷宁
ZHANG Chao;GU Ning(Henan University of Chinese Medicine,Zhengzhou Henan China 450046;The Third Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou Henan China 450008)
出处
《中医学报》
CAS
2022年第6期1348-1352,共5页
Acta Chinese Medicine
基金
河南省中医药科学研究专项课题资助项目(20-21ZY2117)
河南省中医药文化著作出版资助项目(TCM-CB2021023)
河南中医药大学博士基金项目(2016BSJJ-07)。
关键词
胃脘痛
用药规律
冯明清
epigastric pain
medication rule
Feng Mingqing
作者简介
张超(1977-),男,河南汝南人,医学博士,副教授,研究方向:《黄帝内经》病机病证的实验与临床研究;通信作者:谷宁,女,河南南阳人,副主任医师,研究方向:肿瘤及消化内科疾病临床治疗研究。E-mail:guning2000@163.com。
