摘要
Circular RNAs(circRNAs)were shown to play an important role in the occurrence and progression of tumors.However,the functions of nuclear genome-derived circRNAs localized in mitochondria of tumor cells remain largely elusive.Here,we report that circPUMl,a circular RNA derived from back-splicing of pre-mRNAs of nuclear genome PUM1,localizes in mitochondria.
基金
This work was supported by the National Natural Science Foundation of China(81988101,81830086)
Guangdong Basic and Applied Basic Research Foundation(2019B030302012)
CAMS Innovation Fund for Medical Sciences(2019-I2M-5-081)
Major Program of Shenzhen Bay Laboratory(S201101004)
PKU-Baidu Fund(Project 2019BD012).
作者简介
Correspondence:Qimin Zhan,zhanqimin@bjmu.edu.cn;contributed equally:Wei Gong;contributed equally:Jiancheng Xu。
