摘要
目的:探讨窄带成像内镜(NBI)在无典型临床症状血清爱泼斯坦-巴尔病毒(EBV)阳性者鼻咽部活组织检查中的应用效果。方法:选取2017年6月—2020年6月进行检查的无典型临床症状EBV阳性患者150例为研究对象,分别进行鼻咽部NBI活组织检查和鼻咽部普通白光检查,并进行病理活组织检查,以病理检查结果作为金标准,比较NBI活组织检查和普通白光检查的诊断符合率、灵敏度。结果:150例无典型症状血清EBV阳性者病理活组织检查:鼻咽部恶性病变31例(20.67%),非恶性病变119例(79.33%)。NBI内镜对无典型临床症状血清EBV阳性者的诊断符合率为98.00%(147/150),高于普通白光的90.67%(136/150),差异有统计学意义(P<0.05)。NBI内镜对无典型临床症状血清EBV阳性者的诊断灵敏度为96.77%(30/31),高于普通白光的80.64%(25/31),差异有统计学意义(P<0.05)。NBI内镜对无典型临床症状血清EBV阳性者的阳性预测值为93.75%(30/32),高于普通白光的75.76%(25/33),差异有统计学意义(P<0.05)。结论:NBI内镜在无典型临床症状血清EBV阳性者鼻咽部活组织检查中比普通白光检查具有更高的诊断符合率和灵敏度,有望成为一种无典型临床症状血清EBV阳性者鼻咽部活组织检查的重要手段。
Objective:To investigate the efficacy of narrow band imaging(NBI)in nasopharyngeal biopsy of patients with serum epstein-barr virus(EBV)positive without typical clinical symptoms.Methods:Selection in June 2017 to June 2020 in hospital for inspection without typical clinical symptoms of 150 patients with serum EBV positive as the research object,respectively in the nasopharyngeal NBI biopsy and check with the nasopharyngeal ordinary white light,and pathological biopsy,with pathologic examination as the gold standard is the result of the NBI biopsy check the accuracy,sensitivity and ordinary white light.Results:Pathological biopsy of 150 patients with EBV positive without typical symptoms showed that 31 cases(20.67%)had malignant nasopharyngeal lesions and 119 cases(79.33%)had non-malignant lesions.The diagnostic accuracy of NBI endoscopy for EBV positive patients without typical clinical symptoms was 98.00%(147/150),which was higher than that of white light examination(90.67%,136/150),and the difference was statistically significant(P<0.05).The diagnostic sensitivity of NBI endoscopy for EBV positive patients with-out typical clinical symptoms was 96.77%(30/31),which was higher than that of ordinary white light examination(80.64%,25/31),the difference was statistically significant(P<0.05).The positive predictive value of NBI endoscopy for EBV positive patients without typical clinical symptoms was 93.75%(30/32),which was higher than that of ordinary white light examination(75.76%,25/33),the difference was statistically significant(P<0.05).Conclusion:NBI endoscopy has higher diagnostic accuracy and sensitivity than ordinary white light examination in nasopharyngeal biopsy of patients with atypical clinical EBV positive,and is expected to be an important means for nasopharyngeal biopsy of patients with atypical clinical EBV positive.
作者
高天生
李岳桓
黎骋
GAO Tiansheng;LI Yuehuan;LI Cheng(Wuzhou Red Cross Hospital,Wuzhou 543002,China)
出处
《临床医药实践》
2022年第5期348-350,400,共4页
Proceeding of Clinical Medicine
基金
广西壮族自治区卫生和计划生育委员会自筹经费科研课题(项目编号:Z20170645)。
关键词
窄带成像
鼻咽部
鼻咽癌
活组织检查
narrowband imaging
nose pharynx ministry
nasopharyngeal carcinoma
biopsy
作者简介
高天生(1976-),男,广西壮族自治区梧州市人,副主任医师,主要从事鼻咽癌治疗工作。E-mail:liyuehuan54611@163.com。
