摘要
通过模仿天然骨的成分、结构特性对材料进行设计与调控,获得新型仿生人工骨修复材料,这已成为骨修复材料发展的主要趋势之一。静电纺纳米纤维具有可调控的纳米结构、高孔隙率和大比表面积,可以模拟天然细胞外基质的结构和生物功能,被广泛应用于骨组织工程。本文提供一个基于骨组织工程的静电纺纳米纤维的全面概述。首先简要介绍了骨组织工程,并讨论了静电纺原理、参数和典型设备。随后,讨论了静电纺纳米纤维的表面改性方法,并通过关注最具代表性的实例重点介绍了与静电纺纳米纤维和静电纺纳米纤维增强复合材料的应用最相关的最新进展。此外,本综述展望了静电纺纳米纤维未来发展的挑战、机遇以及新方向。
It has become one of the main trends in the development of bone repair materials to design and control materials by imitating the composition and structural characteristics of natural bone to obtain new bionic artificial bone repair materials.Electrospun nanofibers are widely used in bone tissue engineering because of their adjustable nanostructure,high porosity,large specific surface area,and the ability to mimic the structure and biological functions of natural extracellular matrix.This review provides a comprehensive overview of electrospun nanofibers based on bone tissue engineering.We begin with a brief introduction of bone tissue engineering,followed by discussion of electrospinning principle,parameters and typical apparatus.We then discuss surface modification methods of electrospun nanofiber and highlight the most relevant and recent advances related to the applications of electrospun nanofibers and electrospun nanofiber reinforced composites by focusing on the most representative examples.Furthermore,we also offer perspectives of electrospun nanofibers on the challenges,opportunities,and new directions for future development.
作者
牛小连
刘柯君
廖子明
徐慧伦
陈维毅
黄棣
Xiaolian Niu;Kejun Liu;Ziming Liao;Huilun Xu;Weiyi Chen;Di Huang(Research Center for Nano-Biomaterials&Regenerative Medicine,Department of Biomedical Engineering,College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,China;Institute of Applied Mechanics&Biomedical Engineering,Shanxi Key Laboratory of Materials Strength&Structural Impact,Taiyuan University of Technology,Taiyuan 030024,China)
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2022年第2期342-355,共14页
Progress in Chemistry
基金
国家自然科学基金项目(No.11632013,11502158)资助。
关键词
骨组织工程
静电纺丝
工艺参数
表面改性
bone tissue engineering
electrospinning
process parameters
surface modification
作者简介
Corresponding author:黄棣,e-mail:huangjw2067@163.com。
