摘要
目的:探讨小剂量阿司匹林联合拉贝洛尔对子痫前期患者的影响。方法:选取2019年1月-2021年6月阳江市妇幼保健院收治的子痫前期患者110例,简单随机分组为观察组(n=55)与对照组(n=55)。对照组予以拉贝洛尔治疗,观察组在对照组基础上联合小剂量阿司匹林口服,均持续治疗7 d。治疗7 d后,比较两组血压、同型半胱氨酸(Hcy,采用循环酶法检测)、血管紧张素Ⅱ[AngⅡ,采用酶联免疫吸附试验(ELISA)法检测]及24 h尿蛋白(采用免疫比浊法检测)水平,比较用药期间两组不良反应发生率。结果:治疗7 d后,两组收缩压、舒张压均低于治疗前,且观察组低于对照组(P<0.05);两组Hcy、AngⅡ和24 h尿蛋白水平均低于治疗前,且观察组低于对照组(P<0.05);治疗期间,两组呕吐、头晕、心悸和恶心不良反应总发生率对比,差异无统计学意义(P>0.05)。结论:对子痫前期患者采用小剂量阿司匹林联合拉贝洛尔治疗可有效控制血压水平,降低Hcy和AngⅡ水平,安全性较高。
Objective:To investigate the effect of low dose Aspirin combined with Labetalol on preeclamptic patients.Method:A total of 110 preeclamptic patients who were admitted to Yangjiang Maternal and Child Health Hospital from January 2019 to June 2021 were selected and briefly randomized into the observation group(n=55)and the control group(n=55),the control group was treated with Labetalol,and the observation group was treated orally with low dose Aspirin on a control basis,all for 7 d.After 7 d of treatment,blood pressure,hyperhomocysteine(Hcy,detected by using circulating enzyme method),angiotensinⅡ[AngⅡ,detected by using enzyme-linked immunosorbent assay(ELISA)]and 24 hours urine protein(detected by using immunoturbidimetry)levels of the two groups were compared,and the incidence of adverse reactions between the two groups during the medication period was compared.Result:After 7 days of treatment,the systolic and diastolic blood pressure of the two groups were lower than those before treatment,and which in the observation group were lower than those in the control group(P<0.05).The levels of Hcy,AngⅡ,and 24 hours urine protein of the two groups were lower than those before treatment,and which in the observation group were lower than those in the control group(P<0.05).There were no significant differences in the total incidence of vomiting,dizziness,palpitation and nausea between the two groups(P>0.05).Conclusion:The combination of low dose Aspirin and Labetalol treatment in preeclampsia patients can effectively control blood pressure levels and reduce Hcy and AngⅡlevels,with a high safety profile.
作者
关秀莹
周燕
曾靖燕
GUAN Xiuying;ZHOU Yan;ZENGJingyan(Yangjiang Maternal and Child Health Hospital,Yangjiang 529500,China;不详)
出处
《中外医学研究》
2022年第10期103-106,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
