摘要
功能性消化不良(FD)是临床上常见的功能性胃肠病之一。此病的发生与脑-肠轴(BGA)功能失调密切相关。脑肠肽(BGP)是组成BGA的重要因子,分布于脑和胃肠道中。焦虑抑郁情绪可通过影响BGA进而影响BGP在胃肠道及中枢神经系统中的分布,参与FD的发生。中医药在FD合并焦虑抑郁的治疗中应用较为广泛,且多是通过调控BGP的分布来改善患者的胃肠动力、内脏敏感性及焦虑抑郁状态,疗效较为理想。本文从BGA角度阐述FD合并焦虑抑郁的发病原因,并总结相应的治法,为临床上治疗FD合并焦虑抑郁提供理论依据。
Functional dyspepsia(FD)is one of the m ost common functional gastrointestinal diseases in clinic.The occurrence of this disease is closely related to the dysfunction of brain-gut axis(BGA).Brain-gut peptide(BGP)is an important component of BGA,which is distributed in the brain and gastrointestinal tract.Anxiety and depression can affect the distribution of BGP in gastrointestinal tract and central nervous system by affecting BGA,and contribute to the occurrence of FD.Traditional Chinese medicine has been widely used in the treatment of FD combined with anxiety and depression,and it is mainly used to improve gastrointestinal motility,visceral sensitivity and anxiety and depression state of patients by regulating the distribution of BGP.In this paper,the pathogenesis of FD combined with anxiety and depression was explained from the perspective of BGA,and the corresponding treatment was summarized to provide theoretical basis for the clinical treatment of FD combined with anxiety and depression.
作者
张慧丽
杨勤
ZHANG Huili;YANG Qin(Department of Spleen and Stomach Diseases,Nanjing Hospital of Traditional Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing Jiangsu 210000)
基金
江苏省南京市卫生科技发展专项资金项目(YKK20163)。
关键词
功能性消化不良
焦虑抑郁
脑-肠轴
脑肠肽
Functional dyspepsia
Anxiety and depression
Brain-gut axis
ghrelin
作者简介
张慧丽(1997-),女,2019级硕士研究生,研究方向:脾胃病的防治与研究,E-mail:huili18851713020@163.com;通讯作者:杨勤(1969-),女,主任中医师,硕士,研究方向:脾胃病,E-mail:sfy024@njucm.edu.cn。
