摘要
目的探究右美托咪定对腹腔镜下直肠癌根治术患者麻醉苏醒时间及术后认知功能的影响。方法选取湖北理工学院附属黄石爱康医院麻醉科2019年5月至2021年3月进行腹腔镜下直肠癌根治术的患者76例,按随机数字表法分为参照组38例和治疗组38例。治疗组诱导前20 min静脉注射右美托咪定0.8 mg/kg,诱导后以0.5μg/(kg·h)持续静脉注入;参照组给予静脉注射等容量0.9%氯化钠注射液。比较两组患者麻醉前后血流动力学指标、术后认知功能、苏醒时间及并发症。结果麻醉诱导前,两组患者血流动力学各项指标比较,差异无统计学意义(P>0.05);麻醉诱导后,治疗组血流动力学指标显著优于参照组,差异有统计学意义(P<0.05);治疗组麻醉后6、12、24 h的MMSE评分均高于参照组,差异有统计学意义(P<0.05);两组患者的自主呼吸恢复时间、睁眼时间及拔管时间比较,差异无统计学意义(P>0.05);治疗组的呛咳、躁动发生率均低于参照组,差异有统计学意义(P<0.05)。结论腹腔镜下直肠癌根治术给予右美托咪定持续注入,可以稳定患者的血流动力学,改善患者的术后认知功能,减少并发症且不会延迟患者的苏醒时间,值得在直肠癌患者中推广应用。
Objective To explore the effect of dexmedetomidine on the recovery time of anesthesia and postoperative cognitive function of patients undergoing laparoscopic radical resection of rectal cancer.Methods A total of 76 patients who underwent laparoscopic radical resection of rectal cancer in the Department of Anesthesiology of Huangshi Love&Health Hospital Affiliated to Hubei Polytechnic University from May 2019 to March 2021 were selected.They were divided into the control group(n=38)and the treatment group(n=38)according to the random number table method.Patients in the treatment group were intravenously injected with 0.8 mg/kg dexmedetomidine 20 minutes before the induction and 0.5μg/(kg·h)dexmedetomidine after the induction.Patients in the control group were given an equal volume of 0.9%sodium chloride injection via intravenous injection.Hemodynamic indicators,postoperative cognitive function,recovery time and complications of the two groups were compared before and after anesthesia.Results Before anesthesia induction,there was no significant difference in hemodynamic indicators between the two groups(P>0.05);After anesthesia induction,hemodynamic indicators of the treatment group were better than those of the control group,and the difference was statistically significant(P<0.05).The mini-mental state evaluation scores of the treatment group at 6,12,and 24 h after anesthesia were higher than those of the control group,with statistically significant differences(P<0.05).There was no significant difference in recovery time of spontaneous breathing,eye-opening time and extubation time between the two groups(P>0.05).The incidence of cough and agitation were lower in the treatment group than that in the control group,with statistically significant differences(P<0.05).Conclusion Continuous injection of dexmedetomidine in laparoscopic radical resection of rectal cancer can stabilize the hemodynamics,improve the postoperative cognitive function,reduce the complications without delaying the recovery time of patients,which is worth popularization and application in patients with rectal cancers.
作者
姜明
谈海云
余良胜
JIANG Ming;TAN Haiyun;YU Liangsheng(Department of Anesthesiology,Huangshi Love&Health Hospital Affiliated to Hubei Polytechnic University,Hubei,Huangshi 435000,China)
出处
《中国医药科学》
2022年第7期150-153,共4页
China Medicine And Pharmacy
基金
湖北省卫生健康委员会联合基金项目(WJ2019H469)。
关键词
右美托咪定
直肠癌根治术
麻醉苏醒时间
术后认知功能
Dexmedetomidine
Radical resection of rectal cancer
Recovery time of anesthesia
Postoperative cognitive function
作者简介
通讯作者:余良胜。
