摘要
目的:分析复旦大学附属儿科医院厦门分院小儿先天性食管闭锁(CEA)术后院内感染状况。方法:选取复旦大学附属儿科医院厦门分院2015年7月至2021年7月收治的38例CEA患儿作为研究对象,患儿均已行手术治疗,统计其院内感染发生情况、病原菌检查以及药敏试验结果。结果:38例CEA患儿术后出现院内感染的有25例,发生率为65.79 %(25/38)。其中,感染发生部位排名前3的依次为呼吸道、泌尿道、血液系统。38例CEA患儿共检出37份病原菌,术后院内感染的细菌主要为革兰阳性球菌,主要包括表皮葡萄球菌、溶血葡萄球菌、金黄色葡萄球菌、头状葡萄球菌、人葡萄球菌等,且存在耐药现象;药敏试验结果显示,表皮葡萄球菌、溶血葡萄球菌、金黄色葡萄球菌、头状葡萄球菌、人葡萄球菌均对苯唑西林、青霉素耐药,而对替加环素、万古霉素、利奈唑胺均较为敏感。结论:复旦大学附属儿科医院厦门分院CEA患儿术后院内感染发生风险较高,主要部位为呼吸道、泌尿道、血液系统,主要病原菌为革兰阳性球菌,且细菌存在一定的耐药性,临床应对此加以重视,在治疗时积极进行药敏试验,以提高临床疗效。
Objective To analyze the postoperative nosocomial infection in children with congenital esophageal atresia (CEA) in the Children’s Hospital Affiliated to Fudan University.Methods A total of 38 children with CEA admitted to the Children’s Hospital Affiliated to Fudan University from July 2015 to July 2021 were selected as the research subjects.All the children had received surgical treatment,and the incidence of nosocomial infection,pathogen examination and drug sensitivity test results were analyzed.Results Nosocomial infection occurred in 25 of the 38 CEA patients,with an incidence of 65.79% (25/38).The top 3 infection sites were respiratory tract,urinary tract and blood system.A total of 37 pathogenic bacteria were detected in 38 children with CEA.The bacteria mainly infected in postoperative nosocomial were gram-positive cocci,including staphylococcus epidermosis,staphylococcus haemolyticus,staphylococcus aureus,staphylococcus capitalis and staphylococcus hominis,and there was drug resistance.The results of drug sensitivity test showed that staphylococcus epidermidis,staphylococcus haemolyticus,staphylococcus aureus,staphylococcus cephalus and staphylococcus hominis were resistant to benzoxacillin and penicillin,but sensitive to tigecycline,vancomycin and linezolid.Conclusion The Children’s Hospital Affiliated to Fudan University patients with CEA postoperative nosocomial infection risk is higher,the main parts of the respiratory tract,urinary tract,blood system,the main pathogenic bacteria for gram positive coccus,and the drug resistance of bacteria has certain clinical value,this should be in the treatment of active drug sensitive test,in order to improve the clinical curative effect.
作者
刘哓燕
金宏娟
LIU Xiao-Yan;JIN Hong-juan(The Children's Hospital Affiliated to Fudan University,Fujian Xiamen 361000)
出处
《深圳中西医结合杂志》
2022年第2期14-17,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
先天性食管闭锁
院内感染
病原菌检查
药敏试验
Congenital esophageal atresia
Nosocomial infection
Pathogen examination
Drug sensitive text
作者简介
刘哓燕,女,主治医师,主要从事新生儿科相关工作;通信作者:金宏娟,E-mail:jinhj2009@sina.com。
