摘要
水合氯醛是一种安全有效的镇静催眠药,患者在服药后通常可快速镇静或入睡,在儿童镇静方面具有较大的临床价值和现实需求。但由于水合氯醛本身的性质及环境温度、光线等各种因素对其稳定性的影响,水合氯醛相关制剂仍多以医院制剂的形式应用于临床,因此开发单剂量、长效期并能进行自动化大批量生产的水合氯醛制剂,是其后续开发的前景和目标。基于此,本研究通过检索中英文数据库,收集有关水合氯醛各种制剂及其临床应用的相关文献,并进行了综述。
Chloral hydrate is a safe and effective sedative hypnotic medicine. Patients can usually calm down or fall asleep quickly after taking it. It has great clinical value and practical needs in children’s sedation. However,the nature of chloral hydrate itself and various factors such as ambient temperature and light affect its stability of the preparation,most of chloral hydrate preparations are still used in clinic in the form of hospital preparations. Therefore,developing chloral hydrate preparation with single dose,long validity period and automatic mass production is the prospect and goal of its subsequent development. Based on it,this study collects and reviews the relevant literatures on various preparations of chloral hydrate and their clinical application by searching the Chinese and English databases.
作者
陆华
何成章
陈贞伶
黄仁彬
LU Hua;HE Chengzhang;CHEN Zhenling;HUANG Renbin(Dept.of Pharmacy,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;School of Pharmacy,Guangxi Medical University,Nanning 530021,China)
出处
《中国药房》
CAS
北大核心
2022年第8期1021-1024,共4页
China Pharmacy
关键词
水合氯醛
制剂
临床应用
chloral hydrate
preparation
clinical application
作者简介
陆华,主任药师,硕士生导师,博士研究生。研究方向:医院制剂开发。E-mail:hualude@sina.com;通信作者:黄仁彬,教授,博士生导师,博士。研究方向:药物制剂研发。E-mail:huangrenbin518@163.
