摘要
目的 探讨培美曲塞维持化疗对晚期非鳞状细胞非小细胞肺癌(NSCLC)患者的临床疗效。方法 选取2012年1月至2018年12月间辽阳市中心医院收治的接受铂类双药一线化疗的128例非鳞NSCLC患者,根据4个周期后是否接受培美曲塞维持化疗分为维持组(57例)和非维持组(71例),比较两组患者的临床疗效及中位无进展生存时间(PFS)和总生存时间(OS)。结果 两组患者二线治疗方案比较,差异无统计学意义(P>0.05)。128例患者中位PFS为3.3个月(95%CI 2.4~3.7个月),维持组患者中位PFS高于非维持组,差异有统计学意义(P<0.05)。128例患者中位OS为17.1个月(95%CI 8.6~26.8个月),维持组患者中位OS高于非维持组,但差异无统计学意义(P>0.05)。结论 培美曲塞维持性化疗可改善表皮生长因子受体阴性非鳞NSCLC的PFS, OS有延长趋势,需进一步研究探讨。
Objective To investigate the efficacy of maintenance chemotherapy with pemetrexed in patients with advanced non-squamous cell non-small cell lung cancer(NSCLC). Methods A total of 128 patients with non-squamous NSCLC who received platinum-based dual agent as first-line chemotherapy were selected at Liaoyang Central Hospital from January 2012 to December 2018. According to whether they received maintenance pemetrexed chemotherapy after 4 cycles, they were divided into a maintenance group(57 patients) and non-maintenance group(71 patients). Clinical efficacy and median progressive free survival(PFS) and overall survival(OS) were compared between the two groups. Results There was no significant difference in the second-line treatment regimen between the two groups(P>0.05). The median PFS was 3.3 months in the 128 patients(95% CI 2.4 to 3.7 months). The PFS was significantly higher in the maintenance group than in the non-maintenance group(P<0.05). The median OS was 17.1 months in the 128 patients(95% CI 8.6 to 26.8 months) and the median OS was higher in the maintenance group than in the non-maintenance group, but the difference was not statistically significant(P>0.05). Conclusion Maintenance pemetrexed chemotherapy can improve PFS in patients with epidermal growth factor receptor tyrosine kinase negative non-squamous NSCLC, and the OS has a tendency to be prolonged. Further research is needed.
作者
柏晓蔚
寇瑾
BAI Xiao-wei;KOU Jin(Department of Pharmacy,Liaoyang Central Hospital,Liaoyang 111000,China;Department of Oncology,Liaoyang Central Hospital,Liaoyang 111000,China)
出处
《中国肿瘤临床与康复》
2022年第3期324-327,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
非鳞状细胞
癌
非小细胞肺
表皮生长因子受体酪氨酸激酶
培美曲塞
维持性化疗
Non squamous cell
Non-small cell lung cancer
Epidermal growth factor receptor tyrosine kinase
Pemetrexed
Maintenance chemotherapy
作者简介
柏晓蔚,女,主管药师,主要从事临床药学专业。
