摘要
目的:探究罗哌卡因与舒芬太尼围手术期联合镇痛对直肠癌根治术患者免疫功能和血清肿瘤标志物的影响。方法:将106例直肠癌根治术患者分为对照组47例和观察组59例,对照组患者行舒芬太尼静脉自控镇痛,观察组患者在此基础上行罗哌卡因腰方肌阻滞镇痛,观察2组患者手术前后免疫功能、肿瘤标志物及术后各时段疼痛程度。结果:观察组患者术后总淋巴细胞计数(TLC)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)水平均高于对照组(P <0.05);观察组患者术后癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原199(CA19-9)水平均低于对照组(P <0.05);观察组患者术后1h、3h、12h、24h口述分级评分法(VRS)评分均低于对照组(P <0.05)。结论:直肠癌根治术患者围手术期实施罗哌卡因与舒芬太尼联合镇痛效果显著,能有效减轻手术引起的免疫抑制,对降低血清肿瘤标志物水平也可起到积极作用。
Objective To investigate the influence of(ropiracaine+ sufentanil)combiend analgesia at perioperation of radical procedure for rectal cancer on patients’ immuno-function and serum tumor’s markers. Methods The 106 patients with rectal cancer and to be subject to radical procedure were divided into control group(47 cases,received PCIA by using sufentanil)and observation group(59 cases,sufentanil for PCIA combined with ropiracaine for block analgesia via musculus quadratus lumborum);then,both groups’ patients’ immuno-function before and after surgery,tumor’s markers,as well as their pain intensity at different time-points after surgery were observed and compared each other. Results In TLC,and levels of IgG,IgA,IgM;in the levels of CEA,CA-125,CA19-9;as well as,in the VRS ratings at 1,3,12 and 24 hrs after surgery observation group was respectively higher;lower;as well as,lower than control group(all,P<0.05). Conclusion (Ropirancaine+sufentani)combined analgesia at perioperation of radical surgery for rectal cancer has significant analgesia efficacy,can effectively reduce immuno-suppression induced by surgery,also,has active role on declining serum tumors markers’ levels.
作者
余晓菲
吴永伟
李兴晓
YU Xiao-fei;WU Yong-wei;LI Xing-xiao(Dept.of Anesthesia and Perioperative Medicine,the Genernal Hospital of Shenma Medical Group,Pingdingshan,Henan 467000)
出处
《中国肛肠病杂志》
2022年第1期32-34,共3页
Chinese Journal of Coloproctology
作者简介
第一作者:余晓菲,女,河南平顶山人,主治医师,研究方向:麻醉与疼痛。E-mail:597911787@qq.com。
