摘要
The evaluation on prognosis of glioma patients is critical for the individualized treatment.Despite of the widely used mRNA expression level and methylation status of prognostic genes in predicting the patients’prognosis,the clinical application of high-throughput sequencing technology is still limited.Thus,this study aimed to construct a visual and reliable nomogram based on the common clinicopathological parameters for predicting the prognosis of patients diagnosed with high grade glioma(HGG).Notably,age,histopathology,IDH status,1p/19q status,radiotherapy status,chemotherapy status,and tumor recurrence were identified as seven independent prognostic factors for HGG patients.A comprehensive nomogram based on the seven identified factors was subsequently constructed with the remarkable C-index of 0.732.Calibrations for nomogram showed great consistency between the predictive values and the actual values in 1-,3-,and 5-year survival rates.Besides,the areas under the ROC curve(AUC)for predicting 1-,3-,and 5-year survival rates of patients had the values of 0.796(95%CI:0.759-0.833),0.809(95%CI:0.770-0.848),and 0.820(95%CI:0.771-0.869),respectively.Furthermore,an external cohort(n=89)was used to validate the nomogram.In conclusion,age,histopathology,IDH status,1p/19q sta-tus,radiotherapy status,chemotherapy status,and tumor progression were identified as independent prognostic factors,on which a visual predictive model was constructed with powerful predictive value.
作者简介
Shanqiang Qu is an M.D.graduate of Sun Yat-sen University,who is an excellent neurosurgeon.After this doctorate gradu-ation,he engaged in scientific research postdoctoral research in Nanfang Hospital,Southern Medical University.As a neuro-surgery clinician and medical researcher,he has been focusing on the research of"molecular diagnosis and gene therapy of human glioma"and devoted to the early warning and accu-rate treatment of human glioma.Up to now,11 SCI papers have been published as the first author or correspondent au-thor.At present,he is the academic editor of BIO integration journal,and the editorial board member of International Jour-nal of Oncology Research and Therapy journal and Advances in Cancer Research&Clinical Imaging journal;Corresponding author:Zhicheng Hu First Affiliated Hospital of Sun Yat-sen Univer-sity,Associate Chief Physician,Master Supervisor.He has won many awards and published many high-level research papers,and obtained a number of national and Guangdong provincial projects.At present,he is the Executive Guest Editor of The Open Biomarkers Journal.E-mail address:huzhch5@mail.sysu.edu.cn。
