摘要
铁死亡是一种由脂质活性氧驱动的铁依赖形式的调节性细胞死亡, 在肿瘤的发生发展中发挥重要作用。多种临床药物如青蒿素衍生物、伊曲康唑、柳氮磺胺吡啶、葫芦素B、紫杉醇、双硫仑/铜等可通过不同机制诱发头颈部肿瘤铁死亡从而抑制肿瘤生长。对临床常用药物在头颈部肿瘤治疗中诱导铁死亡的调控机制进行研究, 可为头颈部肿瘤铁死亡的靶点治疗提供参考。
Ferroptosis is drived by lipid reactive oxygen species,which plays an important role in the development of tumors.It has been found that a variety of clinical medicines,such as artemisinin derivatives,itraconazole,sulfasala zine,cucurbitacin B,paclitaxel,disulfiram/copper can induce ferroptosis and inhibit tumor growth in head and neck cancer(HNC)through different mechanisms.To study the regulatory mechanism of ferroptosis induced by commonly used drugs in the treatment of HNC can provide reference for the targeted treatment of ferroptosis in HNC.
作者
曾艳
罗盼
王子琪
吴伟莉
Zeng Yan;Luo Pan;Wang Ziqi;Wu Weili(Department of Oncology,School of Clinical Medicine,Guizhou Medical University,Guiyang 550000,China;Department of Oncology,Affiliated Hospital of Guizhou Medical University,Guiyang 5500003;Department of Head and Neck Oncology,Cancer Hospital Affiliated to Guizhou Medical University,Guiyang 550000,China)
出处
《国际肿瘤学杂志》
CAS
2022年第3期173-176,共4页
Journal of International Oncology
基金
国家自然科学基金(82060555)
贵州医科大学国家自然科学基金培育项目(19NSP047)。
关键词
头颈部肿瘤
铁死亡
临床药物
机制
Head and neck neoplasms
Ferroptosis
Clinical medicine
Mechanism
作者简介
通信作者:吴伟莉,Email:wwlmhy@163.com。