摘要
肝脏不典型增生结节(dysplastic nodule,DN)是一组细胞质和细胞核异常而在组织学上无恶性依据,直径在1 cm以上的肝细胞群,是一种肿瘤性病变,属于癌前病变.肝脏DN缺乏特异肿瘤标记物和典型临床症状,主要依靠影像学和组织病理检查诊断,随着对肝脏DN发生机制研究深入和影像学技术的发展,依据病史、各种检查技术特点,个体化选择肿瘤标记物、影像学和组织病理学等技术联合检查,能够显著提高DN早期检出率和诊断准确率,减少误漏诊率.由于肝脏DN具有潜在恶变风险,从发生癌变的各个阶段、各个层面对肝脏DN实施干预,及时去除病因,进行适当治疗,阻断DN向肝细胞癌(hepatocellular carcinoma,HCC)恶变转化进程,对于降低HCC发病率和死亡率具有十分重要的临床意义.
Hepatic dysplastic nodules (DNs) are a group of neoplastic lesions with a diameter of more than 1 cm that belong to precancerous lesions, with abnormal cytoplasm and cells but without malignant basis in histology. Hepatic DNs lack typical tumor markers and clinical symptoms, and their clinical diagnosis relys mainly on imaging or/and tissue pathological examination. Thanks to the further research on the pathogenesis of hepatic DNs and the development of imaging technology, the combination of medical history, various examinationss, individual tumor markers, and imaging and histopathology techniques can significantly improve the early detection and diagnosis accuracy for hepatic DNs, and reduce the rate of missed and false diagnosis. Due to the potential malignancy risk of hepatic DNs, intervention measures should be carried out on hepatic DNs at all stages, in order to block the transformation process of DNs into hepatocellular carcinoma (HCC), which is of great clinical significance to reduce the incidence and mortality of HCC.
作者
盛霞
秦建民
Xia Sheng;Jian-Min Qin(Department of Pathology,Minhang Hospital Affiliated to Fudan University,Shanghai 201100,China;Department of General Surgery,The Third Hospital Affiliated to Naval Military Medical University,Shanghai 201805,China)
出处
《世界华人消化杂志》
CAS
2022年第4期169-181,共13页
World Chinese Journal of Digestology
基金
上海市闵行区医学特色专科项目,No.2020MWFC03.
关键词
肝脏
不典型增生结节
临床特点
诊断
治疗
Liver
Hepatic dysplastic nodule
Clinical features
Diagnosis
Treatment
作者简介
秦建民,教授,主任医师,研究方向为肝癌复发、转移机制与纳米靶向药物治疗;通讯作者:秦建民,教授,主任医师,201805,上海市嘉定区墨玉北路700号,海军军医大学第三附属医院普外科.jianminqin@yahoo.com。
