摘要
目的:评价复方倍他米松联合二氧化碳点阵激光治疗斑秃的临床疗效。方法:将62例斑秃患者随机分成观察组及对照组,每组31例。观察组采用二氧化碳点阵激光治疗,同时超声导入复方倍他米松注射液,2周治疗1次,共12周;对照组单纯采用5%米诺地尔酊外用治疗。观察两组患者治疗前及治疗4、8、12周后临床疗效、皮肤病生活质量指数(DLQI)评分与不良反应。结果:治疗4周后,观察组患者治疗有效率为22.58%,高于对照组的12.90%,差异有统计学意义(P<0.05)。治疗8周后,观察组患者治疗总有效率为80.65%,高于对照组的51.61%,差异有统计学意义(P<0.05)。治疗12周后,观察组患者治疗总有效率为93.55%,高于对照组70.97%,差异有统计学意义(P<0.05)。治疗前,两组患者DLQI评分相比,差异无统计学意义(P>0.05)。两组患者分别进行组内比较,治疗12周后两组患者DLQI评分均较治疗前显著降低,差异有统计学意义(P<0.001)。结论:斑秃患者采用复方倍他米松联合点阵激光治疗可以取得显著的疗效,不良反应小。
Objective:To assess the clinical efficacy of compound betamethasone combined with CO;dot matrix laser in the treatment of alopecia areata.Methods:62 patients with alopecia areata were randomly divided into two groups,including 31 patients per group.The observation group used lattice laser therapy with CO;and sonicated into compound betamethasone injection once in 2 weeks for 12 weeks.The control group was treated with 5% minoxidil tincture.Clinical efficacy of patients.Dermatology life quality index (DLQI) scores and adverse effects at 4,8 and 12 weeks before and after the two groups were observed.Results:After 4 weeks of treatment,the observation group of treatment rate was 22.58%,higher than 12.90% that in the control group,which was statistically significant (P<0.05).After 8 weeks of treatment,the total treatment efficiency of the patients in the observation group was 80.65%,higher than that in the control group 51.61%,which was statistically significant (P<0.05).After 12 weeks of treatment,the total treatment efficiency of the patients in the observation group was 93.55%,higher than 70.97% that in the control group,which was statistically significant (P<0.05).Before treatment,there was no significant difference in their DLQI scores (P>0.05).In-group comparisons were conducted between both groups,and their DLQI score was significantly lower compared with pre-treatment,with a statistically significant difference (P<0.001).Conclusion:Compound betamethasone and lattice laser treatment showed significant efficacy with little adverse effects.
作者
吴燕瑜
齐俊南
邱桂荣
谌莉媚
李金娥
WU Yanyu;QI Junan;QIU Guirong;CHEN Limei;LI Jin'e(Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang Jiangxi 330006,China)
出处
《药品评价》
CAS
2021年第24期1512-1514,共3页
Drug Evaluation
基金
江西省卫生计生委科技计划(20185322)。
作者简介
吴燕瑜,硕士,主治中医师。研究方向:皮肤病学方向,激光美容方向。E-mail:wuyanyu851125@163.com;通信作者:齐俊南,硕士,中医师。研究方向:针灸推拿。E-mail:122824083@qq.com。
