摘要
目的观察^(18)F-FDG PET/CT用于评价脉络膜黑色素瘤(CM)的价值。方法纳入22例临床疑诊为CM的患者,行^(18)F-FDG PET/CT全身显像,进行影像学诊断并测量相关参数。以病理或最终临床诊断为标准,计算PET/CT诊断CM的效能。采用Spearman相关性分析评价最大标准摄取值(SUV_(max))、平均标准摄取值(SUV_(mean))、肿瘤代谢体积(MTV)及病灶糖酵解总量(TLG)与病灶基底最大径、高度之间的相关性。结果22例中,PET/CT诊断20例CM、2例眼球良性病变;其中14例经病理确诊CM,PET/CT诊断CM的敏感度、特异度及准确率分别为100%(14/14)、25.00%(2/8)及72.73%(16/22)。14例CM病灶CT均表现为边界清晰的高密度影,平均CT值(83.96±25.18)HU,病灶基底最大径为(1.46±0.50)cm,高度为0.66(0.50,1.28)cm;PET/CT显示病灶糖代谢均高于对侧眼球,SUV_(max)为5.10(3.44,7.88),SUV_(mean)为3.62(2.37,5.23),MTV为0.68(0.49,1.29)cm^(3),TLG为2.69(1.22,6.08)g。病灶MTV、TLG与病灶基底最大径(r=0.607、0.664,P均<0.05)及高度(r=0.829、0.758,P均<0.05)均呈正相关;SUV_(max)、SUV_(mean)与病灶基底最大径(r=0.493、0.343,P均>0.05)及高度(r=0.464、0.398,P均>0.05)均无显著相关性。结论^(18)F-FDG PET/CT用于评估CM敏感度高、准确率较好,但特异度有限。
Objective To observe the value of ^(18)F-FDG PET/CT for evaluation on choroidal melanoma(CM).Methods A total of 22 patients with clinical suspected CM were enrolled.^(18)F-FDG PET/CT whole-body imaging was performed,and relevant parameters were measured.Taken pathological or final clinical diagnosis as standard,the efficacy of PET/CT for diagnosing CM was calculated.Spearman correlation analysis was used to evaluate the correlation among the maximum standard uptake value(SUV_(max)),the mean standard uptake value(SUV_(mean)),metabolic tumor volume(MTV),total lesion glycolysis(TLG)and the maximum diameter and height of lesion base.Results Among 22 patients,CM was diagnosed in 20 cases,while the other 2 were diagnosed benign ocular lesions with PET/CT,and 14 cases of CM were proved by pathology.The sensitivity,specificity and accuracy of ^(18)F-FDG PET/CT for diagnosis of CM was 100%(14/14),25.00%(2/8)and 72.73%(16/22),respectively.Among 14 CM patients,the lesions showed high density shadow on CT with clear boundary,and the average CT value was(83.96±25.18)HU,the maximum diameter and the height of lesion base was(1.46±0.50)cm and 0.66(0.50,1.28)cm,respectively.PET/CT showed that glucose metabolism of CM lesions were higher than that of the contralateral eyeballs,with SUV_(max) of 5.10(3.44,7.88),SUV_(mean) of 3.62(2.37,5.23),MTV of 0.68(0.49,1.29)cm^(3) and TLG of 2.69(1.22,6.08)g.MTV and TLG of CM lesions were positively correlated with the maximum basal diameter(r=0.607,0.664,both P<0.05)and the height(r=0.829,0.758,both P<0.05)of the base of lesions,whereas SUV_(max) and SUV_(mean) were not significantly correlated with the maximum basal diameter(r=0.493,0.343,both P>0.05)and the height(r=0.464,0.398,both P>0.05)of lesions.Conclusion ^(18)F-FDG PET/CT had high sensitivity and good accuracy for diagnosing CM,but its specificity was rather limited.
作者
韩佩
张水花
唐杰
向楚云
王红依
陈萍
HAN Pei;ZHANG Shuihua;TANG Jie;XIANG Chuyun;WANG Hongyi;CHEN Ping(Department of Nuclear Medicine,Guangzhou Universal Medical Imaging Diagnostic Center,Guangzhou 510000,China)
出处
《中国医学影像技术》
CSCD
北大核心
2022年第2期191-194,共4页
Chinese Journal of Medical Imaging Technology
作者简介
第一作者:韩佩(1985—),女,河南安阳人,本科,主治医师。研究方向。PET/CT肿瘤诊断。E-mail:hanpei1985@163.com;通信作者:陈萍,广州全景医学影像诊断中心核医学部,510000。E-mail:chenping@uvclinic.cn。
