摘要
目的探究血清腺苷脱氨酶(ADA)、乳酸脱氢酶(LDH)及EB病毒(EBV)-DNA对小儿传染性单核细胞增多症(IM)的诊断价值。方法选取安徽六安市人民医院儿科2018年1月至2021年1月收治的IM患儿98例作为研究组,以及同期正常体检儿童40例作为对照组。比较两组的血清ADA、LDH水平及EBV-DNA阳性检出率,运用Pearson相关分析血清ADA、LDH、EBV-DNA相关性。并通过受试者工作特征(ROC)曲线评估各个指标IM的诊断效能。结果研究组血清AD A、LDH水平和EBV-DNA均显著高于对照组,差异有统计学意义(P<0.05);研究组EBV-DNA阳性率为89.8%(88/98),对照组阳性率为5.0%(2/40),两组比较差异有统计学意义(P<0.05)。血清ADA、LDH、EBV-DNA之间均呈正相关(P<0.05)。血清ADA、LDH、EBV-DNA的AUC面积分别为0.872,0.833,0.893。结论血清ADA、LDH及EBV-DNA均能够有效诊断小儿传染性单核细胞增多症,值得推广使用。
Objective To explore the diagnostic value of serum Adenosine deaminase(ADA)、lactate dehydrogenase(LDH)、and EB virus(EBV)-DNA detection in children infectious mononucleosis(IM).Methods From January 2018 to January 2021,98 children with infectious mononucleosis in Department of Pediatrics,Lu’an people’s Hospital,Anhui Province were selected as the research group,and 40 healthy children who passed the physical examination during the same period were selected as the control group.The levels of serum ADA,LDH and the positive detection rate of EBV-DNA were compared between the two groups.The correlation of serum ADA,LDH and EBV-DNA was analyzed by Pearson correlation.and the diagnostic efficacy of each index was evaluated through the receiver operating characteristic(ROC)curve.Results The serum levels of ADA,LDH and EBV-DNA in the study group were significantly higher than those in the control group(P<0.05);the positive rate of EBV-DNA in the study group was 89.8%(88/98),and the positive rate in the control group was 5.0%(2/40),the difference between the two groups was statistically significant(P<0.05).Serum ADA,LDH and EBV-DNA were positively correlated(P<0.05).and LDH was also positively correlated with EBV-DNA(P<0.05).The AUC areas of serum ADA,LDH,and EBV-DNA loads were 0.872,0.833,and 0.893,respectively.Conclusion Serum ADA,LDH and EBV-DNA load detection can effectively diagnose infectious mononucleosis in children,and it is worthy of popularization.
作者
胡杰
李文博
张帆
HU Jie;LI Wenbo;ZHANG Fan(Department 1 of Pediatrics,Lu'an People's Hospital,Lu'an,Anhui,China,237000)
出处
《分子诊断与治疗杂志》
2022年第1期28-31,共4页
Journal of Molecular Diagnostics and Therapy
基金
2018年安徽省医学会急诊临床研究项目(ky2018008)。
作者简介
通信作者:李文博,E⁃mail:282951560@qq.com。
