摘要
目的:探讨妊娠期细菌性感染患者宫颈分泌物菌群的分布及耐药率,为临床合理用药提供依据。方法:选取2020年1月—2021年1月南阳市中心医院收治的妊娠期妇女96例,采集其宫颈分泌物进行细菌培养、鉴定及药敏试验,分析妊娠期妇女细菌性感染宫颈分泌物菌群的分布及其主要革兰阳性菌、主要革兰阴性菌的耐药性。结果:96例妊娠期妇女宫颈分泌物中共分离出病原菌74株,其中革兰阳性菌47株(63.51%),以无乳链球菌(31.08%)、金黄色葡萄球菌(14.86%)、粪肠球菌(10.81%)为主,其次为革兰阴性菌27株(36.49%),以大肠埃希菌(13.51%)、奇异变形杆菌(8.11%)为主;无乳链球菌、金黄色葡萄球菌、粪肠球菌对青霉素、苯唑西林、红霉素的耐药率较高;大肠埃希菌、奇异变形杆菌对哌拉西林、头孢他啶、氨苄西林、头孢唑林的耐药率较高。结论:无乳链球菌、金黄色葡萄球菌、粪肠球菌、大肠埃希菌、奇异变形杆菌是导致妊娠期妇女生殖道感染的主要致病菌,且其对多种常用抗菌药物具有较高的耐药率,临床应根据细菌培养及药敏试验结果合理使用抗菌药物。
Objective: To explore the distribution and drug resistance of cervical secretions in patients with bacterial infection during pregnancy so as to provide theoretical basis for clinical rational drug usage. Methods: 96 pregnant women admitted to a hospital from January 2020 to January 2021 were selected, and their cervical secretions were collected for bacterial culture, identification and drug sensitivity test. The distribution of bacterial flora in cervical secretions of pregnant women with bacterial infection and the drug resistance rates of major Gram-positive and Gram-negative bacteria were analyzed. Results: 74 strains of pathogenic bacteria were isolated from the cervical secretion of 96 pregnant women, among which 47 strains(63.51%) were Gram-positive bacteria, for the most part were group B Streptococcus(31.08%), Staphylococcus aureus(14.86%) and Enterococcus faecalis(10.81%). There were 27 strains of Gram-negative bacteria(36.49%), the most part were Escherichia coli(13.51%) and Proteus strangulis(8.11%). Streptococcus agalactiae, Staphylococcus aureus and Enterococcus faecalis showed higher drug resistance to penicillin, oxacillin and erythromycin. The drug resistance rate of EScherichia coli and Proteus mirabilis to piperacillin, ceftazidime,ampicillin and cefazolin were higher. Conclusion: Streptococcus agalactiae, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Proteus mutans are the main pathogenic bacteria causing reproductive tract infection in pregnant women, and they have a high drug resistance rate to a variety of commonly used antibiotics. Antibiotics should be used rationally based on the results of bacterial culture and drug sensitivity test.
作者
陈一蕊
勾朝阳
李新阳
CHEN Yi-rui;GOU Chao-yang;LI Xin-yang(Medical Laboratory ofNanyarig Central Hospital,Nanyang Henan 473000)
出处
《抗感染药学》
2021年第11期1613-1616,共4页
Anti-infection Pharmacy
关键词
妊娠期妇女
细菌性感染
宫颈分泌物
菌群分布
耐药性
pregnancy
bacterial infection
cervical secretions
flora distribution
drug resistance
作者简介
陈一蕊(1987-),女,主管技师【电子邮箱】:290315706@qq.com。
