摘要
Acute respiratory distress syndrome(ARDS)is a syndrome characterized by significant lung edema,impaired permeability of lung microvascular endothelial cells with the mal-expression of aquaporins(AQPs).In this study,a two-hit porcine model of ARDS induced by smoking and methicillinresistant Staphylococcus aureus(MRSA)was developed,we investigate the AQPs expression and the influence of Ulinastatin(UTI)to them.Forty-nine healthy male domestic pigs aged 8–10 weeks and weighing 30±2 kg were used for the study.Anesthesia was maintained through continuous intravenous infusion of pentobarbital[8 mg/(kg∙h)].A 5-Fr PiCCO catheter(Pulsiocath PV2015L20;Pulsion Medical Systems,Munich,Germany)and a central venous catheter was inserted for hemodynamic monitoring,including mean arterial pressure(MAP),cardiac index(CI),systemic vascular resistance index(SVRI)and extravascular lung water index(ELWI).
作者简介
Correspondence should be addressed to:LI Chun Sheng,E-mail:lichunsheng1962@163.com;Correspondence should be addressed to:WANG Shuo,E-mail:ysys2001@yeah.net,Tel:86-10-87907455;Biographical notes of the first authors:HANG Chen Chen,female,born in 1996,MM,majoring in the field of critical care and cardiopulmonary resuscitation,These authors contributed equally to this work;Biographical notes of the first authors:GUO Yu Hong,female,born in 1976,MD,PhD,majoring in the field of integrated traditional Chinese and western critical care medicine,These authors contributed equally to this work。
