摘要
Wound healing is a complex physiological process that involves coordinated phases such as inflammation and neovascularization.Attempts to promote the healing process tend to construct an effective delivery system based on different drugs and materials.In this paper,we propose novel MXene-integrated microneedle patches with adenosine encapsulation for wound healing.Owing to the dynamic covalent bonding capacity of boronate molecules with adenosine,3-(acrylamido)phenylboronic acid-(PBA-)integrated polyethylene glycol diacrylate(PEGDA)hydrogel is utilized as the host material of microneedle patches.Benefitting from photothermal conversion capacity of MXene,the release of loaded adenosine could be accelerated under NIR irradiation for maintaining the activation signal around injury site.In vitro cell experiments proved the effect of MXene-integrated microneedle patches with adenosine encapsulation in enhancing angiogenesis.When applied for treating animal models,it is demonstrated that the microneedle patches efficiently promote angiogenesis,which is conductive to wound healing.These features make the proposed microneedle patch potential for finding applications in wound healing and other biomedical fields.
出处
《Research》
SCIE
EI
CAS
CSCD
2021年第1期1236-1244,共9页
研究（英文）
基金
was supported by the National Key Research and Development Program of China(2020YFA0908200)
the National Natural Science Foundation of China(52073060 and 61927805)
the Natural Science Foundation of Jiangsu(BE2018707)
the Shenzhen Fundamental Research Program(JCYJ20190813152616459).
作者简介
Correspondence should be addressed to:Yuanjin Zhao,yjzhao@seu.edu.cn。
