20岁以后体质量变化与中年高尿酸血症的关联性研究

Weight changes since age 20 and hyperuricemia in a middle-aged

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摘要目的探讨20岁以后的体质量变化与合肥市中年人群高尿酸血症(HUA)的关联性。方法研究对象为1727例45~60岁的成年人,通过面对面问卷调查、体格及生化指标检查收集资料。采用多因素Logistic回归分析,探究该中年人群20岁以来体质量变化与HUA之间的关联性。结果男性以体质量增加<5 kg组为参照,在调整了年龄、教育程度、吸烟状况和其他混杂因素后,体质量增加5~10 kg、≥10 kg组HUA患病风险均显著增加(OR=2.12,95%CI:1.09~4.13,OR=2.82,95%CI:1.61~4.91);女性以体质量增加<10 kg组为参照,女性体质量增加≥10 kg组HUA患病风险显著增加(OR=3.44,95%CI:1.66~7.13)。结论成年后体质量增加较多显著增加中年HUA的发生风险。 Objective To explore the relationship between weight change since 20 years old and hyperuricemia(HUA)in a middle-aged Hefei population.Methods The subjects were 1727 adults aged 45 to 60.Data was collected through face-to-face questionnaire and physical examination.The relationship between weight change since 20 year and HUA in a middle-aged Hefei population was studied by multivariate logistic regression analysis.Results After adjusting for age,education,smoking and other confounding factors,compared with men who gained<5 kg,the risk of HUA in men who gained 5-10 kg,≥10 kg significantly increased(OR=2.12,95%CI:1.09-4.13,OR=2.82,95%CI:1.61-4.91).Compared with women who gained<10 kg,the risk of HUA in women who gained≥10 kg also significantly increased(OR=3.44,95%CI:1.66-7.13).Conclusion Weight gain in adulthood is associated with an increased risk of HUA,especially in men.

作者陶琪黄瑞程子靳行仪刘开永博庆丽盛韶阳盛杰王素芳 Tao Qi;Huang Rui;Cheng Zi(Dept of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230032)

机构地区安徽医科大学公共卫生学院营养与食品卫生学系安徽医科大学公共卫生学院环境与职业卫生学系

出处《安徽医科大学学报》 CAS 北大核心 2021年第12期1960-1964,共5页 Acta Universitatis Medicinalis Anhui

基金国家自然科学基金(编号:81102125)。

关键词体质量变化高尿酸血症血尿酸 weight change hyperuricemia blood uric acid

分类号 R151.41 [医药卫生—营养与食品卫生学]

作者简介陶琪,女,硕士研究生;王素芳,女,教授,硕士生导师,责任作者,E-mail:1994500012@ahmu.edu.cn。