摘要
糖尿病肾病(DN)是由长期糖尿病(DM)所致的肾脏微血管病变,也是导致终末期肾脏病的主要原因。DN的发病机制涉及广泛,近年的研究表明炎症在其发病过程中起关键作用。在DM患者肾组织中发现细胞黏附分子、生长因子、趋化因子和促炎性细胞因子等表达增加,且与肾功能损伤密切相关。本文讨论了超敏C反应蛋白、中性粒细胞计数与淋巴细胞计数之比、正五聚蛋白3、肿瘤坏死因子-α及其受体、白细胞介素、Nod样受体蛋白3炎症小体、黏附分子、单核细胞趋化蛋白-1等8种与DN发病密切相关的炎症因子,旨在为监测DM患者肾功能变化及早期治疗提供新的思路。
Diabetic nephropathy(DN)is a renal microvascular disease caused by long-term diabetes mellitus(DM),which is also the main cause of end-stage kidney disease.The pathogenesis of DN involves a wide range.Recent studies have shown that inflammation plays a key role in the pathogenesis of DN.Increased expression of cell adhesion molecules,growth factors,chemokines,and pro-inflammatory cytokines is found in the renal tissues of DM patients,which is closely related to renal function injury.Eight inflammatory factors closely related to the pathogenesis of DN,including high sensitivity C-reactive protein,ratio of neutrophil count to lymphocyte count,pentraxin 3,tumor necrosis factor-αand its receptor,interleukins,Nod-like receptor protein 3 inflammasome,adhesion molecule and monocyte chemoattractant protein-1 are discussed in this paper,aiming to provide a new idea for monitoring the renal function changes and early treatment of DM patients.
作者
方雅萱
钟柯
倪清颖
何振洋
杨波
FANG Yaxuan;ZHONG Ke;NI Qingying;HE Zhenyang;YANG Bo(The First Affiliated Hospital of Tianjin University of Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin300380,China)
出处
《中国医药导报》
CAS
2021年第35期38-41,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81774065)。
关键词
糖尿病肾病
炎症因子
生物标志物
炎症反应
微炎症
Diabetic nephropathy
Inflammatory factors
Biomarkers
Inflammatory
Microinflammation
作者简介
方雅萱(1996.9-),女,天津中医药大学第一附属医院2019级中医内科学专业在读硕士研究生,研究方向:中医内科学肾脏病;通讯作者:杨波(1982.3-),男,博士,副主任医师,研究方向:中西医结合肾病临床与基础研究。
