摘要
目的探讨磁共振动态对比增强扫描(DCE-MRI)定量参数与原发性肝癌患者病理特征及缺氧诱导因子-1α(HIF-1α)水平的关系。方法选取2019年1月~2020年12月收治的94例原发性肝癌患者作为研究对象,并选取同期收治的40例肝脏良性结节患者作为对照组。所有受试者均进行DCE-MRI检查,评估两组微血管密度(MVD)、血管内至血管外细胞间隙的转运系数(K^(trans))、血管外细胞外间隙转运至血管内的速率常数(K_(ep))、血管外细胞外间隙体积百分比(V_(e))及HIF-1α。分析肝癌患者中不同肿瘤分期、不同分化程度、是否有转移、不同HIF-1α水平者DCE-MRI定量参数的差异。结果肝癌患者MVD、K^(trans)、K_(ep)、V_(e)及HIF-1α水平均高于对照组(P<0.05);肝癌患者Ⅲ/Ⅳ期者MVD、K^(trans)、K_(ep)、V_(e)水平均高于Ⅰ/Ⅱ期者(P<0.05);肝癌低分化患者MVD、K^(trans)、K_(ep)、V_(e)水平均高于中高分化者(P<0.05);有淋巴结转移的肝癌患者MVD、K^(trans)、K_(ep)、V_(e)水平均高于无淋巴结转移者(P<0.05);HIF-1α≥162.96 ng/L的肝癌患者MVD、K^(trans)、K_(ep)、V_(e)水平均高于HIF-1α<162.96 ng/L者(P<0.05);肝癌临床分期与MVD、V_(e)呈正相关关系(P<0.05),肝癌淋巴结转移与K^(trans)、V_(e)呈正相关关系(P<0.05)。HIF-1α与MVD、K^(trans)、K_(ep)、V_(e)呈正相关关系(P<0.05)。结论DCE-MRI定量参数与原发性肝癌患者病理特征及HIF-1α均密切相关,可利用DCE-MRI定量参数评估肝癌患者病情进展情况。
Objective To investigate the relationship between quantitative parameters of dynamic contrast-enhanced magnetic resonance(DCE-MRI)scanning and pathological features and HIF-1αlevels in patients with primary hepatocellular carcinoma(HCC).Methods A total of 94 patients with primary liver cancer admitted from January 2019 to December 2020 were selected as the study subjects,and 40 patients with benign liver nodules admitted during the same period were selected as the control group.All subjects underwent DCE-MRI to assess microvascular density(MVD),transport coefficient from intracellular space to extracellular space(K_(trans)),rate constant of extracellular space to intracellular space(K_(ep)),percentage of extracellular space volume(V_(e)),and HIF-1αin both groups.The quantitative parameters of DCE-MRI were analyzed among patients with different tumor stages,different degrees of differentiation,whether there was metastasis or not,and different levels of HIF-1α.Results The MVD,K_(trans),K_(ep),V_(e) and HIF-1αin HCC patients were higher than those in control group(P<0.05).The MVD,K_(trans),K_(ep) and V_(e) in stage Ⅲ/Ⅳ were higher than those in stage Ⅰ/Ⅱ (P<0.05).The MVD,K_(trans),K_(ep) and V_(e) in patients with low differentiation were higher than those in patients with high differentiation(P<0.05).The MVD,K_(trans),K_(ep) and V_(e) in HCC patients with lymph node metastasis were higher than those without lymph node metastasis(P<0.05).The MVD,K_(trans),K_(ep) and V_(e) in patients with HIF-1α≥162.96 ng/L were higher than those in patients with HIF-1α<162.96 ng/L(P<0.05).The clinical stage of HCC was positively correlated with MVD and V_(e)(P<0.05),and lymph node metastasis of HCC was positively correlated with K_(trans) and V_(e)(P<0.05).The HIF-1αwas positively correlated with MVD,K_(trans),K_(ep) and V_(e)(P<0.05).Conclusion DCE-MRI quantitative parameters are closely related to the pathological characteristics and HIF-1αof HCC patients,and they can be used to evaluate the disease progression of HCC patients.
作者
何承峻
杨小丁
陈海洋
HE Chengjun;YANG Xiaoding;CHEN Haiyang(Department of General Surgery,The First People's Hospital of Ziyang,Ziyang 641300,China)
出处
《分子影像学杂志》
2021年第6期969-973,共5页
Journal of Molecular Imaging
基金
四川省医学科研课题(S17083)。
关键词
磁共振动态对比增强扫描
血管内至血管外细胞间隙的转运系数
血管外细胞外间隙转运至血管内的速率常数
微血管密度
缺氧诱导因子-1Α
MRI dynamic contrast enhanced scanning
transport coefficient of intercellular space from intravascular to extravascular
rate constant of extracellular space transport into the vessel
microvascular density
hypoxia-inducible factor-1α
作者简介
何承峻,硕士,主治医师,E-mail:hechengjun1986@yeah.net。
