摘要
目的 研究加速康复外科(ERAS)在腹腔镜胆囊切除术患者中应用对术后全身炎症应激状态和康复质量的影响。方法 134例行腹腔镜胆囊切除术患者,根据随机数字表法分为对照组和观察组,每组67例。对照组患者应用常规康复干预,观察组患者应用ERAS干预。比较两组患者的术后全身炎症应激状态指标[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、皮质醇、肾上腺素]、并发症发生情况及其他康复指标。结果 术后24、48 h,观察组患者的hs-CRP、IL-6、TNF-α、皮质醇和肾上腺素水平均低于对照组,差异具有统计学意义(P<0.05)。观察组患者术后并发症发生率为5.97%,与对照组的10.45%比较差异无统计学意义(P>0.05)。观察组患者术后肛门首次排气时间、下床活动时间和住院时间分别为(18.90±2.50)h、(7.23±1.32)h、(3.49±0.56)d,均短于对照组的(24.30±2.90)h、(12.98±2.10)h、(5.10±0.84)d,差异具有统计学意义(P<0.05)。结论 ERAS干预的实施有助于促进腹腔镜胆囊切除术患者术后全身炎症应激反应的减轻,促进术后康复,值得推广。
Objective To study the effect of enhanced recovery after surgery(ERAS)on systemic inflammatory stress and rehabilitation quality in patients undergoing laparoscopic cholecystectomy.Methods A total of 134 patients undergoing laparoscopic cholecystectomy were divided into control group and observation group according to the random numerical table,with 67 cases in each group.Patients in the control group received conventional rehabilitation intervention,and patients in the observation group received ERAS intervention.Both groups were compared in terms of postoperative systemic inflammatory stress indicators[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),cortisol,adrenaline],complications and other rehabilitation indicators.Results At 24 and 48 h postoperatively,hs-CRP,IL-6,TNF-α,cortisol and epinephrine in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The postoperative complication rates in the observation group was 5.97%,which was not statistically significant compared with 10.45%in the control group(P>0.05).In the observation group,the postoperative anal exhaust time,off-bed activity time,and hospitalization time were(18.90±2.50)h,(7.23±1.32)h,and(3.49±0.56)d,respectively,which were shorter than(24.30±2.90)h,(12.98±2.10)h,and(5.10±0.84)d of the control group,and the difference was statistically significant(P<0.05).Conclusion The implementation of ERAS intervention helps to promote the reduction of postoperative systemic inflammatory stress in patients undergoing laparoscopic cholecystectomy,and promote postoperative rehabilitation.It is worthy of promotion.
作者
谭伟鹤
TAN Wei-he(Fengcheng Hospital of Traditional Chinese Medicine,Dandong 118100,China)
出处
《中国现代药物应用》
2021年第22期238-240,共3页
Chinese Journal of Modern Drug Application
关键词
腹腔镜胆囊切除术
加速康复
术后康复
全身炎症应激状态
Laparoscopic cholecystectomy
Enhanced recovery after surgery
Postoperative rehabilitation
Systemic inflammatory stress response
