摘要
目的 探讨前列地尔注射液联合尿毒清颗粒对慢性肾功能不全患者的治疗效果。方法 94例慢性肾功能不全患者,按照入院顺序分为对照组与观察组,每组47例。对照组采用前列地尔注射液治疗,观察组在对照组基础上联合尿毒清颗粒治疗。比较两组患者临床疗效、治疗前后肾功能指标[尿素氮(BUN)、血肌酐(Scr)、内生肌酐清除率(Ccr)、血清β_(2)微球蛋白(β_(2)-MG)]、凝血功能指标(凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原)及不良反应发生情况。结果 观察组治疗总有效率为93.62%,显著高于对照组的78.72%,差异具有统计学意义(P<0.05)。治疗后,观察组Scr(91.62±18.43)μmol/L、BUN(5.61±1.26)mmol/L、β_(2)-MG(1210.37±341.26)mmol/L、24 h尿蛋白定量(0.91±0.24)g/24 h低于对照组的(117.64±20.31)μmol/L、(8.43±1.55)mmol/L、(1864.75±328.56)mmol/L、(1.31±0.30)g/24 h,Ccr(52.84±8.61)ml/min高于对照组的(45.67±7.89)ml/min,差异具有统计学意义(P<0.05)。观察组凝血酶原时间(8.85±2.13)s、活化部分凝血活酶时间(26.44±4.96)s、纤维蛋白原(3.01±0.98)g/L与对照组的(8.78±2.11)s、(26.27±5.01)s、(3.23±1.01)g/L对比,差异无统计学意义(P>0.05)。两组不良反应发生率对比差异无统计学意义(P>0.05)。结论 采用前列地尔注射液联合尿毒清颗粒治疗慢性肾功能不全,可明显改善患者临床病症,修复受损肾功能,安全可靠。
Objective To discuss the therapeutic effect of alprostadil injection combined with Niaoduqing granules on patients with chronic renal insufficiency.Methods A total of 94 patients with chronic renal insufficiency were divided into control group and observation group according to the order of admission,with 47 cases in each group.The control group was treated with alprostadil injection,and the observation group was treated with Niaoduqing granules on the basis of the control group.Both groups were compared in terms of clinical efficacy,renal function indexes[blood urea nitrogen(BUN),serum creatinine(Scr),endogenous creatinine clearance(Ccr),serumβ_(2) microglobulin(β_(2)-MG)],coagulation function indexes(prothrombin time,activated partial thromboplastin time,fibrinogen)before and after treatment,and the occurrence of adverse reactions.Results The total effective rate of treatment in the observation group was 93.62%,which was significantly higher than 78.72%in the control group,and the difference was statistically significant(P<0.05).After treatment,the Scr(91.62±18.43)μmol/L,BUN(5.61±1.26)mmol/L,β_(2)-MG(1210.37±341.26)mmol/L,24 h urinary protein quantification(0.91±0.24)g/24 h of the observation group were lower than(117.64±20.31)μmol/L,(8.43±1.55)mmol/L,(1864.75±328.56)mmol/L,(1.31±0.30)g/24 h of the control group,and the Ccr(52.84±8.61)ml/min was higher than(45.67±7.89)ml/min of the control group.All the differences were statistically significant(P<0.05).The prothrombin time(8.85±2.13)s,activated partial thromboplastin time(26.44±4.96)s,fibrinogen(3.01±0.98)g/L in the observation group were not statistically different from(8.78±2.11)s,(26.27±5.01)and(3.23±1.01)g/Lin the control group(P>0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Alprostadil injection in combination with Niaoduqing granules is safe and reliable in the treatment of chronic renal insufficiency,and it can obviously improve the clinical symptoms and repair damaged renal function of patients.
作者
董晓辉
DONG Xiao-hui(First People’s Hospital of Jinzhou District,Dalian 116000,China)
出处
《中国现代药物应用》
2021年第22期9-12,共4页
Chinese Journal of Modern Drug Application
关键词
慢性肾功能不全
前列地尔注射液
尿毒清颗粒
肾功能
不良反应
Chronic renal insufficiency
Alprostadil injection
Niaoduqing granules
Renal function
Adverse reactions
