期刊文献+

Research Progress of Protein Tyrosine Phosphatase Receptor-Type 0 in Hepatocellular Carcinoma

在线阅读 下载PDF
导出
摘要 Hepatocellular carcinoma(HCC)is one of the most common malignant tumors in the world with a high incidence and has become one of the most malignant cancers worldwide.Its clinical treatment mainly includes surgical intervention,chemotherapy,and iirununotherapy,with poor curative effect and prognosis.In recent years,with the development of basic research,it has been revealed that protein tyrosine phosphatase receptor-type O(PTPRO)plays an important role in the pathogenesis of hepatocellular carcinoma.Protein tyrosine phosphatase receptor-type O is a new type of protein tyrosine phosphatase,which has been proven to inhibit oncoprotein.In this paper,the potential mechanism of protein tyrosine phosphatase receptor-type O in the progression of hepatocellular carcinoma is discussed to provide reference for clinical treatment and drug development.
出处 《Proceedings of Anticancer Research》 2021年第6期94-97,共4页 抗癌研究
作者简介 Corresponding author:Xinke Xie,xiexinke0928@163.com。
  • 相关文献

参考文献8

二级参考文献137

  • 1Zhu W, Qin W, Hewett JE, et al. Quantitative evaluation of DNA hypermethylation in malignant and benign breast tissue and fluids [ J ]. Int J Cancer,2010,126 ( 2 ) :474 - 482.
  • 2Baylin SB, Herman JG, Graft JR, et al. Alterations in DNA methyla- tion : a fundamental aspect of neoplasia[ J]. Adv Cancer Res, 1998, 72 : 141 - 196.
  • 3Jones PA, Laird PW. Cancer epigenetics comes of age[ J]. Nat Gen- et,1999,21 (2) :163 -167.
  • 4Jones PA, Takai D. The role of DNA methylation in mammalian epi- genetics [ J ]. Science ,2001,293 (5532) : 1068 - 1070.
  • 5Arimura Y, Yagi J. Comprehensive expression profiles of genes for protein tyrosine phosphatases in immune cells[J]. Sci Signal, 2010,3(137) :rsl.
  • 6Fischer EH. Cell signaling by protein tyrosine phosphorylation[J]. Adv Enzyme Regul, 1999,39:359 - 369.
  • 7Laczmanska I, Sasiadek MM. Tyrosine phosphatases as a superfami- ly of tumor suppressors in eoloreetal cancer[ J]. Aeta Biochim Pol, 2011,58 (4) :467 - 470.
  • 8Gupta S, Radha V, Sudhakar C, et al. A nuclear protein tyrosine phosphatase activates p53 and induces caspase - 1 - dependent ap- optosis [ J ]. FEBS Lett,2002,532:61 - 66.
  • 9Salmeen A, Andersen JN, Myers MP, et al. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B [ J ]. Mol Cell, 2000,6 : 1401 - 1412.
  • 10Alonso A, Sasin J, Bottini N, et al. Protein tyrosine phosphatases in the human genome[ J ]. Cell ,2004,117:699 - 711.

共引文献38

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部