摘要
Following recent insights on structure-cell-function interactions and the critical role of the extracellular matrix(ECM),the latest biofabrication approaches have increasingly focused on designing materials with biomimetic microarchitecture.Divergence electrospinning is a novel fabrication method for three-dimensional(3D)nanofiber scaffolds.It is introduced to produce 3D nanofiber mats that have numerous applications in regenerative medicine and tissue engineering.One of the most important characteristics of 3D nanofiber mats is the density gradient.This study provides a statistical analysis and response surface modeling framework based on experimental data to evaluate the manner by which the geometric designs of double-bevel collectors influence the fiber density gradient.Specifically,variance of analysis and sensitivity analysis were performed to identify parameters that had significant effects,and a response surface model embedded with seven location indicators was developed to predict the spatial distribution of fiber density for different collector designs.It was concluded that the collector height,bevel angle,and their interactions were significant factors influencing the density gradient.This study revealed the sensitivity of system configuration and provided an optimization tool for process controllability of microstructure gradients.
作者简介
Muhammad Adib Uz Zaman,is currently a Ph.D.candidate of Industrial En gineering and research fellow at Texas Tech University.His research interests are predictive modeling,data science and operations research.He earned a bachelor's and a master's degree in Industrial Engineering from Bangladesh University of Engineering and Technology and Northern Illinois University,respectively in 2015 and 201&To know more about his research,kindly visit his research webpage:https://auzipe.wixsite.com/adib;Dilshan Sooriyaarachchi,is a PhD candidate in Industrial.Manufacturing and Systems Engineering at Texas Tech University.His current research aims to generate new knowledge and breakthroughs by integrating different manufacturing technologies into novel processes and manufacturing platforms.To this end he worked on the development of a highly effective scaffold that incorporates multiple manufacturing technologies to mimic physical and architectural properties of a native human organ for optimal tissue regeneration.His most recent work focuses on the design and manufacturing of a ZnO nanowire anchored microfluidic device capable of collecting urine extracellular vesicles(EVs)encapsulated miRNA at a high efficiency.Dilshan Sooriyaarachchi received his B.S.in Physics from University of Colombo,Sri Lanka in physics from Texas Tech in 2013 and his master's degree University;Ying-Ge Zhou,is a Ph.D.candidate in the Department of Industrial,Manufacturing&Systems Engineering at Texas Tech University.His current research focuses on microfabrication and hybrid manufacturing of 3D biomimetic architecture for biomedical applications.He made a major contribution to developing an innovative electrospinning strategy that induces rapid selfassembly of aligned 3D nanofiber scaffolds which create a biomimetic environment to facilitate cell morphogenesis.He also conducted pioneering work on the integration of silver nanoparticles and microcurrent for antimicrobial ultrafiltration membranes.His most recent work focuses on rapid fabrication of nanoporous microtubes as artificial capillary vessels for tissue engineering.He has published sixteen refereed journal papers and three conference papers.His teaching interests include Manufacturing Systems,Additive Manufacturing Processes&Systems,and Biomedical Design and Manufacturing.Ying-Ge earned his B.S.in Mechanical Engineering,and Business Administration at Xiangtan University,China in 2014,and his Master's degree in Industrial Engineering from Texas Tech University in 2016.He is a member of USE and ASME;Dr.George Z.Tan,is an Assistant Professor of Industrial,Manufacturing and Systems Engineering(IMSE)at Texas Tech University(TTU).Dr.Tan received his Ph.D.in Industrial&Systems Engineering from North Carolina State University in 2015 and joined the IMSE Department at TTU as an Assistant Professor in fall 2016.He directs the Tissue Assembly and Nanofabrication(TAN)Laboratory.His laboratory is working on novel fabri cation technologies for multifunctional materials and biomimetic structures,including electrospinning,3D bioprinting,direct-write photolithography,and crystal self-assembly.His work in biofabrication focuses on creating biomimetic cell microenvironment closely resembling the natural fibrous extracellular matrix.He has made multiple original contributions in developing biomimetic scaffold with micro-and nanoscale topographical features;Dr.Dong-Ping Du,received the B.S.and M.S.degrees in electrical engineering from the China University of Mining and Technology.Beijing,China,and the Ph.D.degree in industrial engineering from the University of South Florida,Tampa,FL,USA.She is currently an Assistant Professor at the Department of Industrial.Manufacturing,and Systems Engineering,Texas Tech University,Lubbock,TX,USA.Her research focuses on nonlinear stochastic modeling and analysis of complex systems with applications in healthcare and systems engineering.Her research interests include computer simulation and optimization,stochastic modeling,data science,and applied statistics.Dr.Du received IBM best paper award from IEEE EMBC,and two of her papers were highlighted by the IEEE Journal of Biomedical and Health Informatics.She is a member of IEEE,INFORMS,and USE.dongping.du@ttu.edu。
