摘要
脓毒血症(sepsis)是指机体对感染的反应失调导致危及生命的多器官功能障碍。脓毒血症是重症监护患者死亡的主要原因,但其诱发多器官功能衰竭的机制至今仍未阐明。线粒体是细胞重要的细胞器,承担细胞内能量供应及信号调节等多种功能。线粒体功能障碍可能是脓毒血症导致多器官功能衰竭的重要原因之一。本文阐述了线粒体的病理生理功能及其在脓毒血症多器官功能衰竭中的可能损伤机制,并总结了脓毒血症中着眼于线粒体开展的治疗方案,为临床脓毒血症提供治疗靶点或新思路。
Sepsis is life-threatening multiple organ failure(MOF)caused by the disorder of body's response to infection.Although it is the main reason of death in intensive care patients,the mechanism of sepsis-induced MOF is still unclear.As an essential organelle of cells,mitochondrial is responsible for many funtions in cells such as energy supply and signal regulation.Recent researches showed that mitochondrial dysfunction may be one of the important reasons of MOF.This review describes the pathophysiological functions of mitochondria and the pathological damage mechanisms of MOF in sepsis,it will provide the therapeutic targets or new ideas for clinical treatment of sepsis.
作者
魏艳龙
董孝彧
尚志文
张共鹏
程志鹏
高琴
WEI Yanlong;DONG Xiaoyu;SHANG Zhiwen;ZHANG Gongpeng;CHENG Zhipeng;GAO Qin(Clinical Medical College,Bengbu Medical College,Bengbu 233000,Anhui,China;Department of Physiology,Bengbu Medical College,Bengbu 233000,Anhui,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2021年第11期1292-1299,共8页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然科学基金项目(81770297)
国家大学生创新创业项目(202010367014,202010367061)。
作者简介
魏艳龙,男,本科生,研究方向:心血管损伤与修复,Tel:19855081882,E-mail:985545236@qq.com;通信作者:高琴,女,博士,教授,硕士生导师,研究方向:心血管损伤与修复,Tel:18909659912,E-mail:bbmcgq@126.com。
