靶控输注与静脉推注丙泊酚联合阿芬太尼在妇科腹腔镜手术维持麻醉中的应用效果比较被引量：7

Comparison of effects of target-controlled infusion and intravenous bolus of Propofol combined with Alfentanil in maintenance anesthesia during gynecological laparoscopic surgeries

在线阅读下载PDF

导出

摘要目的:比较靶控输注与静脉推注丙泊酚联合阿芬太尼在妇科腹腔镜手术维持麻醉中的应用效果。方法:选取100例妇科腹腔镜手术患者作为研究对象,按照随机数字表法分为对照组和观察组各50例。对照组静脉推注丙泊酚联合阿芬太尼维持麻醉,观察组靶控输注丙泊酚联合阿芬太尼维持麻醉,比较两组不同时间血流动力学指标[心率(HR)、平均动脉压(MAP)]水平、麻醉恢复时间、手术前后炎性因子[血清白细胞介素-6(IL-6)、皮质醇(Cor)、C反应蛋白(CRP)]水平和不良反应发生率。结果:插管即刻、手术开始5 min、手术开始30 min、术毕时,观察组HR、MAP均低于对照组,差异有统计学意义(P<0.05);观察组定向力恢复时间、睁眼时间、自主呼吸时间及拔管时间均短于对照组,差异有统计学意义(P<0.05);观察组CRP、IL-6、Cor水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:靶控输注丙泊酚联合阿芬太尼应用于妇科腹腔镜手术维持麻醉,可降低血流动力学指标水平和炎性因子水平,缩短麻醉恢复时间,效果优于静脉推注丙泊酚联合阿芬太尼维持麻醉。 Objective:To compare effects of target-controlled infusion and intravenous bolus of Propofol combined with Alfentanil in maintenance anesthesia during gynecological laparoscopic surgeries.Methods:100 patients undergoing gynecological laparoscopic surgeries were selected as the research objects,and were divided into control group and observation group according to the random number table method,50 cases in each group.The control group received intravenous infusion of Propofol combined with Alfentanil for anesthesia,while and the observation group was given f target-controlled infusion of Propofol combined with Alfentanil for anesthesia.The hemodynamic indicator levels at different times[heart rate(HR),mean arterial pressure(MAP)],the anesthesia recovery time,the inflammatory factor levels before and after the surgery[serum interleukin-6(IL-6),cortisol(Cor),C-reactive protein(CRP)]and the incidence of adverse reactions were compared between the two groups.Results:Immediate intubation,5 minutes from the start of the operation,30 minutes from the start of the operation,and after the operation,the HR and the MAP of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The orientation recovery time,the eye-opening time,the spontaneous breathing time and the extubation time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).The levels of CRP,IL-6 and Cor in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Propofol combined with Alfentanil target-controlled infusion for maintenance anesthesia for the patients undergoing gynecological laparoscopic surgeries can reduce the levels of hemodynamic indicators and the inflammatory factors,and shorten the anesthesia recovery time.Moreover,it is superior to Propofol combined with Alfentanil intravenous infusion for maintenance anesthesia.

作者李云龙 LI Yunlong(Department of Anesthesiology of Yuxi Maternal and Child Health Hospital,Yuxi 653100 Yunnan,China)

机构地区玉溪市妇幼保健院麻醉科

出处《中国民康医学》 2021年第21期143-145,共3页 Medical Journal of Chinese People’s Health