摘要
目的探讨高同型半胱氨酸(HHcy)与急性缺血性脑卒中患者神经功能损伤、动脉粥样硬化形成的关系。方法选取宝鸡市第三人民医院2018年2月至2019年4月收治的100例急性缺血性脑卒中患者作为研究对象,根据其入院时血清Hcy浓度分为HHcy组54例(血清Hcy≥10μmol/L)和NHcy组46例(血清Hcy水平<10μmol/L);比较两组患者的体质量指数(BMI)、血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、入院时美国国立卫生院卒中量表(NIHSS)评分、颈动脉内膜中膜厚度(IMT)、颈动脉粥样硬化斑块积分等指标。采用Pearson法、多元线性回归法分析以上各项指标之间的相关性。结果HHcy组患者的IMT为(1.84±0.28)mm、颈动脉粥样硬化斑块积分为(3.96±1.55)分,明显高于NHcy组的(1.48±0.22)mm、(2.64±1.10)分,差异均具有统计学意义(P<0.05);急性缺血性脑卒中患者的IMT、颈动脉粥样硬化斑块积分与患者血清Hcy均呈显著的正相关性(r=0.471、0.503,P<0.05);以收缩压、TG、HbA1c、Hcy、IMT、颈动脉粥样硬化斑块积分作为自变量,以NIHSS评分作为因变量,建立Logistic回归模型,结果显示收缩压、TG、Hcy、IMT、颈动脉粥样硬化斑块积分与NIHSS评分增高呈正相关关系(P<0.05)。结论血清Hcy升高与颈动脉粥样硬化形成具有相关性,与急性脑缺血患者神经功能损伤程度有关。
Objective To explore the relationship between high homocysteine(HHcy)and neurological damage and atherosclerosis in patients with acute ischemic stroke.Methods A total of 100 patients with acute ischemic stroke admitted to Third People’s Hospital of Baoji City from February 2018 to April 2019 were selected as the research objects.According to the serum levels of Hcy at the time of admission,they were divided into 54 cases in HHcy group(serum Hcy≥10μmol/L)and 46 cases in NHcy group(serum Hcy<10μmol/L).The body mass index(BMI)and the levels of serum triacylglycerol(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),fasting blood glucose(FPG),and glycosylated hemoglobin(HbA1 c)were compared between the two groups,as well as the National Institutes of Health Stroke Scale(NIHSS)at admission,carotid intima-media thickness(IMT),and the carotid atherosclerotic plaque score.Pearson method and multiple linear regression method were used to analyze the correlation between the above indicators.Results The IMT of the HHcy group was(1.84±0.28)mm,and the carotid atherosclerotic plaque score was(3.96±1.55)points,which were significantly higher than(1.48±0.22)mm and(2.64±1.10)points of the NHcy group(P<0.05).The IMT and carotid atherosclerotic plaque scores of patients with acute ischemic stroke were significantly positively correlated with the patient’s serum Hcy(r=0.471,0.503,P<0.05).With systolic blood pressure,TG,HbA1 c,Hcy,IMT,carotid atherosclerotic plaque score as independent variables,and NIHSS score as dependent variable,a logistic regression model was established.The results showed that systolic blood pressure,the level of TG,Hcy and IMT,and carotid atherosclerosis plaque score were positively correlated with the increase of NIHSS score(P<0.05).Conclusion The increase of serum Hcy is related to carotid atherosclerosis,and it is related to the degree of neurological damage in patients with acute cerebral ischemia.
作者
李世芳
王联军
LI Shi-fang;WANG Lian-jun(Internal Medicine-Neurology,Third People's Hospital of Baoji City,Baoji 712000,Shaanxi,CHINA)
出处
《海南医学》
CAS
2021年第22期2887-2890,共4页
Hainan Medical Journal
作者简介
通讯作者:王联军,E-mail:wanglianjunyisheng@163.com。
