摘要
环状RNA(circular RNA,circRNA)是一类具有稳定共价闭合环状结构的非编码RNA。该类RNA不仅在肿瘤的发生发展中起着重要作用,还是多种疾病诊断和治疗的新型生物标志物。滋养细胞功能障碍可导致胚胎着床失败、胎盘发育异常及母-胎界面血管重塑不足,进而造成早期妊娠丢失、子痫前期、早产及胎儿生长受限(fetal growth restriction,FGR)。本文主要从子痫前期、复发性流产(recurrent spontaneous abortion,RSA)、FGR等方面阐述circRNA近年来在滋养细胞功能障碍相关疾病的研究进展,以便更好地理解妊娠相关疾病的发病机制,进而为疾病的诊治提供新思路。
Circular RNAs(circRNAs),non-coding RNA with stable circular covalently closed structures,provide new biomarkers for the diagnosis and treatment of various diseases and play an important role in the development of tumors.Trophoblast dysfunction can cause embryo implantation failure,placental dysplasia,and insufficient vascular remodeling at the maternal-fetal interface,leading to early pregnancy loss,preeclampsia(PE),premature delivery,and fetal growth restriction(FTR).Here,we review recent research progress in circRNAs in diseases related to trophoblast dysfunction such as PE,recurrent spontaneous abortion(RSA)and FGR.In this way,we can better understand the pathogenesis of pregnancy-related diseases and come up with new ideas for their future diagnosis and treatment.
作者
谢来娣
刘爱霞
Xie Laidi;Liu Aixia(Women′s Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,China)
出处
《中华生殖与避孕杂志》
CSCD
北大核心
2021年第9期850-856,共7页
Chinese Journal of Reproduction and Contraception
基金
国家重点研发计划项目(2018YFC1004403)。
关键词
环状RNA
子痫前期
复发性流产
胎儿生长受限
子宫内膜容受性
Circular RNA
Preeclampsia
Recurrent spontaneous abortion
Fetal growth restriction
Endometrial receptivity
作者简介
通信作者:刘爱霞,Email:liuaixia@zju.edu.cn,电话:+86-571-87061501。
