摘要
基于层层(LBL)自组装技术,在Pt-Cu纳米合金表面依次包覆带正电的聚赖氨酸(PLL)和带负电的透明质酸(HA),成功构筑Pt-Cu@PLL@HA纳米平台。HA不仅延长了纳米平台血液循环时间,还可实现肿瘤主动靶向作用,提升肿瘤部位富集效果。在肿瘤区域透明质酸酶(HAase)作用下HA快速降解,释放Pt-Cu@PLL(+)颗粒,有利于肿瘤细胞特异性摄取。基于Pt-Cu合金良好的近红外二区(NIR-Ⅱ)吸收性能,实现了NIR-Ⅱ光声成像引导的NIR-Ⅱ光热高效抗肿瘤效果。
A nanoplatform Pt-Cu@PLL@HA based on Pt-Cu nano-alloys encapsulated in the positively charged polylysine(PLL)and negatively charged hyaluronic acid(HA)was constructed via layer-by-layer(LBL)self-assem-bly technology.HA not only prolonged the blood circulation time of Pt-Cu@PLL@HA,but also realized the active tu-mor targeting and enhanced its high accumulation in tumor region.After fast HA degradation in response to hyal-uronidase(HAase)in the tumor microenvironment,the site-specific exposure of Pt-Cu@PLL(+)was conducive to the uptake of tumor cells.Owing to the strong NIR-Ⅱ(the second near-infrared window)absorption capability of Pt-Cu alloy,the effective photothermal tumor ablation could be realized by the precise guidance of NIR-Ⅱphotoacoustic imaging.
作者
郑子良
曲波涛
杨晓荣
刘玲
张瑞平
ZHENG Zi-Liang;QU Bo-Tao;YANG Xiao-Rong;LIU Ling;ZHANG Rui-Ping(Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Taiyuan 030032,China)
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2021年第11期1991-2001,共11页
Chinese Journal of Inorganic Chemistry
基金
国家自然科学基金(No.81571747,81771907)
山西省面上青年基金(No.201901D211343)资助。
关键词
近红外二区
光热治疗
光声成像
Pt-Cu合金
层层自组装
the second near-infrared window
photothermal therapy
photoacoustic imaging
Pt-Cu alloy
layer-by-layer self-assembly
作者简介
共同第一作者:郑子良;共同第一作者:曲波涛#。;通信联系人:张瑞平。E-mail:zrp_7142@sxmu.edu.cn。
