摘要
目的探讨肥胖患者瘦素水平与冠心病的关系。方法选取2018年9月至2020年1月广西医科大学第一附属医院心内科收治的胸痛查因(未有冠心病史)择期做冠状动脉造影的肥胖患者(BMI≥27kg/m2)作为研究对象,根据冠状动脉造影结果将患者分为冠心病组和对照组,对两组进行性别、年龄1∶1匹配后,剩下46对作为最终研究对象。结果多元线性回归分析显示,性别(女性,R2=0.545,β=0.580,P<0.001)、年龄(R2=0.545,β=0.245,P=0.006)、高密度脂蛋白(R2=0.545,β=0.228,P=0.014)是瘦素的影响因素。多因素logistic回归分析结果显示,血清瘦素水平与冠心病独立相关(每增加1个标准差,OR=2.350,95%CI1.234~4.475,P=0.009);当瘦素水平转化为分类变量进行分析时,最高三分位组患冠心病风险比最低三分位组高3.854倍(P=0.048)。结论在肥胖人群中,瘦素水平升高与冠心病独立相关。
Objective To investigate the association between serum leptin levels and the risk of coronary artery disease(CAD) in people with obesity. Method The symptomatic patients with BMI≥27 kg/m2(without CAD history) who underwent diagnostic coronary angiography in the First Affiliated Hospital of Guangxi Medical University, from September 2018 to January 2020 were selected. Based on the angiographic results, patients were divided into CAD group and control group. With 1∶1 age and sex matched, a total of 46 pairs were eligible and included for the final analysis. Results In multiple linear regression analysis, independent determinants of leptin variability were age(R2=0.545, β =0.245, P=0.006)、sex(female, R2=0.545, β =0.580, P<0.001) and high-density lipoprotein cholesterol(R2=0.545, β=0.228, P=0.014). In multiple binary logistic regression, increased serum leptin levels were independently associated with the risk of CAD(OR=2.350, per 1-standard deviation, 95%CI 1.234~4.475,P=0.009). When leptin levels were analyzed as an ordinal variable, the risk of CAD was 3.854-fold(P=0.048) higher in the highest quartile than that in the lowest quartile. Conclusion Elevated leptin level is associated with an increased risk of CAD in people with obesity.
作者
王灿
罗秋湖
覃春雨
见闻
陈务贤
WANG Can;LUO Qiu-hu;QIN Chun-yu;JIAN Wen;CHEN Wu-xian(Department of Cardiology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《中国心血管病研究》
CAS
2021年第10期905-909,共5页
Chinese Journal of Cardiovascular Research
基金
广西医疗卫生适宜技术开发与推广应用项目(S2017036)
广西南宁市青秀区科学研究与技术开发计划(2017030)。
关键词
冠心病
瘦素
肥胖人群
相关性
Coronary artery disease
Leptin
People with obesity
Correlation
