摘要
目的应用脑动脉自旋标记磁共振技术(ASL-MRI),探讨阿尔茨海默病(AD)患者脑血流变化特点及其与认知功能的关系。方法选择2020年9月至2021年3月就诊于北京中医药大学东直门医院门诊、病房的AD患者13例为AD组,13例年龄、性别匹配的认知功能正常受试者为正常对照组。对2组受试对象采用ASL-MRI进行皮质脑血流定量测量,采用神经心理学量表进行认知功能综合评价。采用t检验比较2组受试者不同脑区脑血流的差异,以受试者操作特征曲线下面积(AUC)评价各脑区脑血流值对AD的诊断效能,并应用Pearson相关分析各脑区脑血流与认知功能的关系。结果与正常对照组相比,AD组脑血流普遍减慢,其中中央前回、额中回、后扣带回及左侧颞中叶的脑血流下降[(30.44±8.02)ml(/100 g·min)vs(42.63±12.89)ml(/100 g·min);(29.73±15.70)ml(/100 g·min)vs(47.44±14.30)ml/(100 g·min);(39.69±13.31)ml/(100 g·min)vs(58.84±15.98)ml/(100 g·min);(40.87±14.62)ml(/100 g·min)vs(56.92±16.47)ml(/100 g·min)],差异具有统计学意义(t=2.410、2.500、2.762、2.186,P=0.028、0.024、0.014、0.044),这些区域对诊断AD具有一定价值(AUC=0.78、0.80、0.83、0.78)。额中回及左侧后扣带回的脑血流与简易精神状态检查量表定向力评分呈正相关关系(r=0.489、0.511,P=0.040、0.030)。结论AD患者脑血流普遍下降,其中额中回和后扣带回区域下降明显,且与认知功能评分相关。
Objective To investigate the characteristics of cerebral blood flow(CBF)in Alzheimer's disease(AD)and its relationship with cognitive function by arterial spin labeling magnetic resonance imaging(ASL-MRI).Methods Thirteen AD patients admitted to Dongzhimen Hospital,Beijing University of Chinese Medicine from September 2020 to March 2021 were included as the AD group;and other 13 cognitively normal subjects with age and gender matched were included as the normal control group.The cortical CBF was measured by ASL-MRI,and their cognitive function was evaluated by neuropsychological scales.The receriver operating characteristic curve was used to evaluate the diagnostic efficacy of CBF value in each brain region for AD,and correlation analysis was used to study the relationship between CBF in different brain regions and cognitive function.Results The cerebral blood flow in AD group generally showed decreased compared with the normal control group,especially the cerebral blood flow in the anterior central gyrus,middle frontal gyrus,posterior cingulate gyrus,and left middle temporal lobe[(30.44±8.02)ml/(100 g·min)vs(42.63±12.89)ml/(100 g·min),(29.73±15.70)ml/(100 g·min)vs(47.44±14.30)ml/(100 g·min),(39.69±13.31)ml/(100 g·min)vs(58.84±15.98)ml/(100 g·min),(40.87±14.62)ml/(100 g·min)vs(56.92±16.47)ml/(100 g·min)].These differences were statistically significant(t=2.410,2.500,2.762,2.186;P=0.028,0.024,0.014,0.044).These areas may be of value in the diagnosis of AD(area under curve=0.78,0.80,0.83,0.78).CBF of middle frontal gyrus and left posterior cingulate gyrus were positively correlated with MMSE orientation score(r=0.489,0.511;P=0.040,0.030).Conclusion CBF in AD patients generally decreased,especially in the middle frontal gyrus and posterior cingulate gyrus,which was related to the score of cognitive function.
作者
周英奕
时晶
魏明清
倪敬年
李婷
张立苹
谭中建
田金洲
Zhou Yingyi;Shi Jing;Wei Mingqing;Ni Jingnian;Li Ting;Zhang Liping;Tan Zhongjian;Tian Jinzhou(rd Department of Neurology,Beijing University of Chinese Medicine,Beijing 100700,China;College of Acupuncture-Moxibustion and Tuina,Beijing University of Chinese Medicine,Beijing 100029,China;Department of Radiology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中华脑血管病杂志（电子版）》
2021年第5期302-307,共6页
Chinese Journal of Cerebrovascular Diseases(Electronic Edition)
关键词
阿尔茨海默病
脑血流
动脉自旋标记
磁共振
认知功能
Alzheimer's disease
Cerebral blood flow
Arterial spin
Magnetic resonance imaging
Cognitive function
作者简介
通信作者:田金洲,Email:jztian@hotmail.com。
