摘要
[背景]成年居民的肥胖率和高尿酸血症患病率呈现不断上升趋势,然而肥胖与高尿酸血症的关联性分析结果并不一致。[目的]探讨我国四省成年居民全身性肥胖、中心性肥胖与高尿酸血症患病是否有关联。[方法]本研究数据来源于"神经系统疾病专病社区队列研究"2018—2019年基线数据。选择有完整人口学信息、体格测量和血清尿酸检测等数据的15 918名18岁及以上成年居民作为研究对象。全身性肥胖程度(包括超重和肥胖)使用体质指数(BMI)判定,中心性肥胖程度使用腰围和腰臀比判定。分析不同特征研究对象的血清尿酸水平和高尿酸血症患病情况。采用多因素logistic回归分析全身性肥胖、中心性肥胖与高尿酸血症患病的关联性。[结果]我国四省18岁及以上成年男性居民和女性居民血清尿酸平均浓度分别为346.3、291.3μmol·L-1,高尿酸血症加权患病率分别为21.7%和14.4%。超重、肥胖和中心性肥胖人群的血清尿酸水平及患病率均高于正常人群(P<0.001),且高尿酸血症患病人群的BMI、腰围、腰臀比高于非高尿酸血症人群(P<0.001)。多因素logistic回归分析结果显示:与BMI正常组相比,超重组和肥胖组的男性居民患高尿酸血症的OR分别是1.86(95%CI:1.62~2.13)和2.98(95%CI:2.49~3.56),超重组和肥胖组的女性居民患高尿酸血症的OR分别是1.58(95%CI:1.38~1.80)和2.51(95%CI:2.15~2.93);与腰围正常组相比,腰围过高组(中心性肥胖)的男性和女性居民患高尿酸血症的OR分别是1.80(95%CI:1.58~2.05)和1.82(95%CI:1.61~2.07);与腰臀比正常组相比,腰臀比过高组(中心性肥胖)的男性和女性居民患高尿酸血症的OR分别是1.65(95%CI:1.46~1.87)和1.78(95%CI:1.56~2.04)。[结论]全身性肥胖和中心性肥胖与高尿酸血症相关。
[Background] The prevalence of obesity and hyperuricemia among adult residents is on the rise. However, the studies’ results on the correlation between obesity and hyperuricemia are not consistent. [Objective] This study aims to explore the relationships of general obesity and central obesity with hyperuricemia among adult residents in four provinces of China.[Methods] The data were derived from the baseline data of "Community-based Cohort Study on Nervous System Diseases" from 2018 to 2019. A total of 15 918 adult residents aged 18 years and above who had complete demographic characteristics, physical measurements, and laboratory test data were selected as study subjects. General obesity(overweight and obesity) was measured by body mass index(BMI), and central obesity by waist circumference and waist-to-hip ratio. The serum uric acid level and prevalence of hyperuricemia were analyzed among participants with different characteristics. A multiple logistic regression analysis was used to analyze the correlations of general obesity and central obesity with hyperuricemia.[Results] The average serum uric acid levels of male and female adults aged 18 years and over in the four provinces of China were 346.3 μmol·L-1 and 291.3 μmol·L-1, respectively, and the weighted prevalence rates of hyperuricemia were 21.7% and 14.4%. The serum uric acid levels and prevalence rates of the overweight, obese, and central obesity groups were higher than those of the normal population(P< 0.001), and the BMI, waist circumference, waist-to-hip ratio of the hyperuricemia group were higher than those of the non-hyperuricemia group(P< 0.001). The results of multiple logistic regression analysis showed that compared with the normal BMI group, the OR values of hyperuricemia in overweight and obese men were 1.86(95% CI: 1.62-2.13) and 2.98(95% CI: 2.49-3.56), respectively, and the OR values of hyperuricemia in overweight and obese women were 1.58(95% CI: 1.38-1.80) and 2.51(95% CI: 2.15-2.93), respectively. Compared with the normal waist circumference group, the OR values of hyperuricemia in male and female adults with high waist circumferences(central obesity) were 1.80(95% CI: 1.58-2.05) and 1.82(95% CI: 1.61-2.07), respectively. Compared with the normal waist-to-hip ratio group, the OR values of hyperuricemia in male and female adults with high waist-to-hip ratios(central obesity) were 1.65(95% CI: 1.46-1.87) and 1.78(95% CI: 1.56-2.04), respectively.[Conclusion] General obesity and central obesity are associated with the prevalence of hyperuricemia.
作者
胡浩杰
宋晓昀
金东辉
李瑞强
张力博
贾文虎
王志宏
王惠君
苏畅
HU Haojie;SONG Xiaoyun;JIN Donghui;LI Ruiqiang;ZHANG Libo;JIA Wenhu;WANG Zhihong;WANG Huijun;SU Chang(Public Nutrition Department,National Institute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijing 100050,China;Hunan Provincial Center for Disease Control and Prevention,Changsha,Hunan 410005,China;School of Public Health,Hebei Medical University,Shijiazhuang,Hebei 050017,China;Pucheng County Center for Disease Control and Prevention,Weinan City,Pucheng,Shaanxi 715500,China;Huanglong County Center for Disease Control and Prevention,Yan'an City,Huanglong,Shaanxi 715700,China)
出处
《环境与职业医学》
CAS
CSCD
北大核心
2021年第9期1015-1021,共7页
Journal of Environmental and Occupational Medicine
基金
国家重点研发计划项目(2017YFC0907701)。
关键词
高尿酸血症
体质指数
腰围
腰臀比
肥胖
hyperuricemia
body mass index
waist circumference
waist-to-hip ratio
obesity
作者简介
胡浩杰(1996-),女,硕士生,E-mail:15732683256@163.com;通信作者:苏畅,E-mail:suchang@ninh.chinacdc.cn。
